lyme disease keratitis. 19892729417
extrapyramidal features in central lyme borreliosis.we report 5 cases with an extrapyramidal syndrome resulting from borrelia burgdorferi encephalitis which responded to antibiotic treatment. the acute onset of extrapyramidal features together with diffuse pain can be the leading symptoms of central borreliosis.19892731563
demonstration of spirochetes in cardiac biopsies of patients with lyme disease.cardiac involvement occurring early in borrelia burgdorferi infection is a clinical manifestation of human lyme disease. therefore, two patients with acute complete atrioventricular heart blocks and unexplained recurrent dizziness were studied. both patients had significantly elevated serum titers of igm and igg antibodies to b. burgdorferi. right ventricular subendocardial biopsies showed dense infiltrates consisting of lymphocytes and plasma cells. silver staining revealed spirochetes characte ...19892732509
ingestion of lyme disease spirochetes by ticks feeding on infected hosts. 19892732513
identification and characterization of an endoflagellar antigen of borrelia burgdorferi.the 41-kd antigen of borrelia burgdorferi is an immunodominant protein that is recognized early by antibodies in sera from lyme disease patients and known to be associated with the endoflagella. we identified the 41-kd endoflagellar antigen to be a single polypeptide with an apparent isoelectric point (pi) of 6.5 by two-dimensional (2-d) electrophoresis. this polypeptide, which we designated p41f alpha, was heavily labeled by 125i in 2-d autoradiographs of b. burgdorferi whole-cell lysates and w ...19892738156
[articular involvement in swiss patients with a borrelia burgdorferi infection--report of 8 cases].eight cases of lyme's arthritis are reported. in four of them, they are related to an erythema chronicum migrans, in two to an acrodermatitis atrophicans. in two cases, there was no cutaneous manifestation, but the serology was strongly positive for borrelia burgdorferi, and there was rapid relief of the pain with antibiotic therapy. it is suggested that lyme's arthritis is not rare in switzerland and that it must be searched for in every case of arthritis of unknown etiology, especially when th ...19892740677
[lyme disease: epidemiology].lyme disease, known primarily from north america, with three main foci in the united states, and from temperate europe, particularly in france, seems to be increasing in incidence. wherever it is known to exist, it has become the most prevalent tick-borne disease of man. the natural cycle of the etiologic agent, borrelia burgdorferi, involves ticks as vectors and wild rodents as reservoirs. in infected areas, everyone walking or, especially, working in forested areas is at risk of tick bites, es ...19892740780
lyme-borreliosis and possible association with hla-antigens.the frequencies of hla a, b, c and dr antigens were evaluated in 220 persons from west germany with inapparent and manifest borrelia burgdorferi infections. thirty-seven forest workers showing elevated antibody titres against borrelia burgdorferi had asymptomatic infection, and are described as stage 0. one hundred and eighty-three patients presented with the clinical stages 1-3 of the infection. control persons (n = 655) were typed in the same time period and by identical staff. hla cw3 was pre ...19892741164
meningoradiculoneuritis mimicking vertebral disc herniation. a "neurosurgical" complication of lyme-borreliosis.we report on 3 patients with meningoradiculoneuritis (mrn) due to lyme-borreliosis (lb), which presented clinically as vertebral disc herniation. in 2 cases the underlying infection was discovered only after unsuccessful neurosurgical treatment. in the differential diagnosis between mrn and disc herniation the following criteria are suggestive of mrn and should raise suspicion of a non-discogenic aetiology: history of tick bite or erythema chronicum migrans, fever or general malaise, mono- or ol ...19892741734
central nervous system manifestations of lyme disease.we studied six patients with central nervous system manifestations of lyme disease. weeks to years after the initial infection, behavioral changes, ataxia, and/or weakness in bulbar or peripheral muscles developed. four of the six patients had a lymphocytic pleocytosis in the cerebrospinal fluid, and two of them had magnetic resonance imaging scans suggestive of demyelination. in a patient with a subacute encephalitis, a brain biopsy specimen showed microgliosis without an inflammatory infiltrat ...19892742551
treatment of clothing with a permethrin spray for personal protection against the western black-legged tick, ixodes pacificus (acari: ixodidae).the synthetic pyrethroid, permethrin, when applied to clothing with a pressurized spray at an application rate estimated previously to be 4 micrograms a.i./cm2, was found to be 100% effective for personal protection against all three parasitic stages of the western black-legged tick, ixodes pacificus cooley and kohls. this tick has been implicated as the primary vector of the lyme disease spirochete (borrelia burgdorferi) to humans in the far-western united states. periods of exposure to permeth ...19892743839
concurrent neuroborreliosis and alzheimer's disease: analysis of the evidence.several recent reports have claimed a possible association between borrelia burgdorferi infection and alzheimer's disease (ad). herein, we describe our search for additional evidence of neuroborreliosis in ad. brain tissue from neuropathologically confirmed cases of ad was cultured for b burgdorferi using standard microbiologic methods. material derived from culture was further examined using electron microscopy, direct immunofluorescence and acridine orange fluorescence. previous studies have s ...19892744748
myositis caused by borrelia burgdorferi: report of four cases.myositis was proven histopathologically in 4 patients (age range 36-66 years) who suffered from early or late stages of borrelia burgdorferi infection. muscle weakness was present in 3 patients, 1 complaining of additional myalgias. one man came to medical attention because of skin discoloration and swelling of one leg. deep biopsy from skin, fascia and muscle revealed acrodermatitis chronica atrophicans, panniculitis, fasciitis, and myositis, respectively. creatine kinase was slightly elevated ...19892746290
lyme disease in manitoba. 19892752450
distribution of the lyme disease agent in wildlife reservoirs in ontario. 19892752451
reinfection with borrelia burgdorferi. 19892758830
lyme disease. 19892758859
[unusual manifestations of lyme borreliosis. a contribution to the clinical spectrum of this disease group].since the discovery that em (erythema migrans), aca (acrodermatitis chronica atrophicans) and bl (borrelial lymphocytoma) have an infectious etiology, these syndromes have been receiving particular attention. this report describes four patients whose dermatological symptoms did not at first indicate borreliosis. in all four cases serological antibody tests proved that they were caused by borrelia burgdorferi. in two of these cases these findings were confirmed by bacterial cultures. the unusual ...19892759856
lameness and asymptomatic borrelia burgdorferi seropositivity in dogs. 19892760490
analysis of north american and european isolates of borrelia burgdorferi with antiserum to a recombinant antigen. 19892760492
adherence of the lyme disease spirochete to glial cells and cells of glial origin.lyme disease, a tick-borne spirochetosis caused by borrelia burgdorferi, produces protean neurologic manifestations, yet its neuropathogenesis is poorly understood. the affinity of the spirochete for cells of primary rat brain cultures and of the c6 glioma cell line was studied. b. burgdorferi adhered to both types of cells in a dose-dependent manner and exhibited an affinity for an extracellular matrix produced by the primary and by glioma cell cultures. adherence of the spirochetes to the glia ...19892760500
locked-in state in borrelia burgdorferi meningitis.the case is reported of a 28-year-old woman with persistent tetraplegia following acute meningitis due to borrelia burgdorferi infection. the patient developed erythema chronicum migrans before radicular pain occurred in the upper extremities. the poor clinical outcome was suggestive of pontine infarction due to vasculitis of branches of the basilar artery.19892760649
molecular analysis of linear plasmid-encoded major surface proteins, ospa and ospb, of the lyme disease spirochaete borrelia burgdorferi.the ospa and ospb genes encode the major outer membrane proteins of the lyme disease spirochaete borrelia burgdorferi. the deduced translation products from the ospa and ospb genes were: (ospa) 273 amino acids long with a molecular weight of 29,334, and (ospb) 296 amino acids long with a molecular weight of 31,739. the two osp proteins showed a great degree of sequence similarity indicating a recent evolutionary event. molecular analysis and sequence comparison of ospa and ospb with other protei ...19892761388
megabase-sized linear dna in the bacterium borrelia burgdorferi, the lyme disease agent.using pulsed-field gel electrophoresis we examined the genome of borrelia burgdorferi, a eubacterium of the spirochete phylum and the agent of lyme disease. a population of this species' cells was lysed in situ in agarose blocks. an abundant dna form that behaved as a linear duplex molecule under different electrophoretic conditions was found. the estimated size of the molecule was 950 kilobases. dna from two other genera of spirochetes did not enter the gel under these conditions. these studies ...19892762306
late stage lyme borreliosis in children.these cases illustrate that late stage lyme borreliosis can occur in children without a history of tick bite or ecm; this disorder can manifest itself initially as a seventh cranial nerve palsy, heart block, or arthritis, and the arthritis syndrome can mimic oligoarticular juvenile rheumatoid arthritis. the diagnosis of lyme borreliosis depends upon clinical recognition. in the absence of ecm, tests for antibodies to borrelia burgdorferi can provide an invaluable tool in assisting in the diagnos ...19892762902
complete heart block as the sole presentation of lyme disease.we report a case of lyme myocarditis presenting solely as complete heart block in a previously healthy 32-year-old white man. indium cardiac antimyosin scan showed diffuse uptake (2+, on a scale of 0 to 4+) during the acute phase of the illness. the electrocardiogram and the indium cardiac antimyosin scan were normal 6 weeks after completion of tetracycline and prednisone treatment. lyme carditis should be considered in the differential diagnosis of complete heart block of unclear origins, even ...19892764661
a tick, in time, may cause lyme (disease). 19892768012
ear punch biopsy method for detection and isolation of borrelia burgdorferi from ear punch biopsy method for the detection and isolation of borrelia burgdorferi from rodents was developed. the ear punch biopsy proved to be extremely sensitive, detecting spirochetes in 100% (11 of 11) of laboratory hamsters infected by tick bite and 95.8% (23 of 24) of hamsters infected by intraperitoneal inoculation. when cultured at 4 to 6 weeks postinfection, 92 to 100% of the ear punches taken from individual hamsters yielded viable spirochetes. b. burgdorferi was detected in sequentia ...19892768461
identification of borrelia burgdorferi and b. hermsii using dna hybridization probes.fragments of plasmid dna from borrelia burgdorferi and b. hermsii were cloned and tested for specificity as hybridization probes to identify these two species of pathogenic spirochetes. three fragments from the 49-kilobase-pair linear plasmid of b. burgdorferi were tested: a 500-base-pair (bp) hindiii fragment (probe 49a), a 445-bp psti-hindiii fragment (probe 3g), and a 320-bp hindiii fragment (probe 16h). when hybridized to purified dna or whole spirochetes, all of the probes distinguished b. ...19892768462
lyme disease in california: interrelationship of ixodes pacificus (acari: ixodidae), the western fence lizard (sceloporus occidentalis), and borrelia burgdorferi.the relationship of immature western black-legged ticks, ixodes pacificus cooley and kohls, to the western fence lizard, sceloporus occidentalis baird and girard, and to the lyme disease spirochete, borrelia burgdorferi, was investigated in chaparral and woodland-grass habitats in northern california from 1984 to 1986. immature ticks were found on lizards in spring and summer, but the prevalence and abundance of ticks on this host were considerably greater in spring. the peak of larval abundance ...19892769705
[meningoradiculitis caused by borrelia burgdorferi]. 19892772302
[lyme disease with a 12-year course and serologic diagnosis]. 19892772332
survival of borrelia burgdorferi in blood products.the incidence of lyme disease is rapidly increasing in the united states. to assess the potential of transmission of the disease through blood transfusion, we studied the survival of borrelia burgdorferi in blood products under blood bank storage conditions. two units of whole blood, separated into red cells (rbcs), fresh-frozen plasma (ffp), and platelet concentrates (pcs), were inoculated with b. burgdorferi (strain b31) in concentrations of approximately 3000 organisms per ml of rbcs and ffp ...19892773025
lyme disease concurrent with human immunodeficiency virus infection. 19892773968
interstitial cystitis and borrelia burgdorferi. 19892774376
taking a second hard look at borrelia burgdorferi. 19892777700
rapid flow cytometric studies of borrelia burgdorferi phagocytosis by human polymorphonuclear leukocytes.the interactions between a strain of borrelia burgdorferi and human polymorphonuclear leukocytes were studied by flow cytometry in the presence of specific or non-specific opsonizing factors. the capacity of the borrelias to stimulate leukocyte metabolism was also investigated. the results indicated that a low phagocytosis by isolated purified polymorphonuclear leukocytes did occur in the presence or absence of specific antibodies. within whole blood the percentages of phagocytosting leukocytes ...19892777724
penetration of doxycycline into cerebrospinal fluid in patients treated for suspected lyme neuroborreliosis.twelve patients were treated orally with 100 mg of doxycycline twice a day (b.i.d.) and 10 patients were treated with 200 mg b.i.d. for suspected tick-borne neuroborreliosis (lyme borreliosis). at 5 to 8 days after the start of therapy, the mean concentrations in serum were 4.7 micrograms/ml for the doxycycline dose of 100 mg b.i.d. and 7.5 micrograms/ml for 200 mg b.i.d., 2 to 3 h after the last drug administration. the corresponding levels for cerebrospinal fluid were 0.6 and 1.1 micrograms/ml ...19892782858
lyme disease and migrating birds in the saint croix river valley.during a study of migrating land birds in 1987, we examined over 9,200 individual birds representing 99 species from the saint croix river valley, a lyme disease-endemic area of east central minnesota and northwestern wisconsin. we found that 250 deer tick (ixodes dammini) larvae and nymphs infested 58 birds from 15 migrant species; 56 ticks (22.4%) were positive for the lyme disease spirochete borrelia burgdorferi. five ground-foraging migrant bird species favoring mesic habitats, veery (cathar ...19892782872
[lyme borreliosis and its significance for the ent physician].lyme disease is a tick-borne multisystemic borrelia infection to which the following diseases belong: erythema migrans, lymphadenosis benigna cutis, lymphocytic meningoradiculitis (bannwarth's syndrome), lyme-arthritis and acrodermitis chronica atrophicans. the infection rate of ticks with borrelia burgdorferi in germany amounts to 13.6% compared to the infection with the european spring summer meningoencephalitis virus with 1.1%. recent investigations show that lipopolysaccharides and interleuk ...19892784972
[incidence and clinical spectrum of borrelia burgdorferi infection in spain. study group for lyme disease in spain]. 19892786124
comparing the relative potential of rodents as reservoirs of the lyme disease spirochete (borrelia burgdorferi).the authors compared the contribution of white-footed mice (peromyscus leucopus), chipmunks (tamias striatus), and meadow voles (microtus pennsylvanicus) to infection of vector ticks with the lyme disease spirochete, borrelia burgddorferi. at one massachusetts location where lyme disease is endemic, all three species of rodents were found to be infected. prevalence of infection, however, varied from 90% for mice, and 75% for chipmunks to just 5.5% for meadow voles. infectivity of these hosts for ...19892787105
isolation of interleukin 1 from joint fluids of patients with lyme investigate the role of interleukin 1 (il-1) in lyme arthritis we assayed synovial fluids (sf) for the presence of il-1 activity. crude sf from patients with lyme disease showed il-1-like activity. chromatography of joint fluids revealed activity at 15-20,000 daltons. two populations of cells were grown, which produced significant il-1 activity when stimulated with the lyme disease spirochete or its lipopolysaccharide. il-1 activity from sf or stimulated cells was neutralized with an antihuma ...19892789287
lyme disease vector, ixodes dammini, identified in manitoba. 19892791076
meningoencephalomyeloradiculoneuritis in one case of borrelia burgdorferi infection (lyme disease).we describe a patient having serologically confirmed borrelia burgdorferi infection manifesting meningoencephalomyeloradiculoneuritis. the clinical and mri features suggested a multifocal vascular nervous system involvement. emg-eng showed abnormalities consistent with axonal degeneration initially involving the more proximal segments of the lower limb nerves.19892793421
testing for borrelia burgdorferi. 19892793554
rheumatoid arthritis subsequent to borrelia burgdorferi infection in two dogs.two dogs with clinical signs of polyarthritis developed rheumatoid arthritis subsequent to borrelia burgdorferi infection. in both dogs, the diagnosis of b burgdorferi infection was based on clinical signs of disease and high serum b burgdorferi titer. after antibiotic administration, both dogs had decreased b burgdorferi titer, but clinical response was temporary or was lacking. the dogs subsequently were rheumatoid factor-positive (antinuclear antibody- and anti-globulin-negative) and responde ...19892793577
concurrent positive serology for ehrlichiosis and lyme disease. 19892794568
lyme disease: tick vectors, distribution, and reservoir hosts. 19892794809
myositis during borrelia burgdorferi infection (lyme disease).during the second stage of an illness caused by borrelia burgdorferi, a young woman developed a myopathic syndrome characterised by severe muscular pains, incapacitating weakness of the proximal limb and the neck, as well as the bulbar muscles and elevated serum ck levels. muscle biopsy revealed a non-inflammatory necrotising myopathy. b. burgdorferi infection was confirmed by a considerable rise of specific igg antibodies. a course of high dose steroids alleviated the myalgias, but paresis bega ...19892795056
meningoradiculitis and encephalomyelitis due to borrelia burgdorferi: a follow-up study of 72 patients over 27 1987, follow-up studies were conducted on 72 patients who had had meningoradiculitis and encephalomyelitis (8 patients) due to borrelia burgdorferi 5-27 years previously. these patients had not been treated with antibiotics, either during the acute disease or during the interval prior to follow-up studies. the patients had exhibited the typical symptoms of bannwarth's syndrome during the acute phase. at the follow-up studies, 33 patients showed no, and 23 only mild, clinical residual symptoms ...19892795099
[borrelia burgdorferi infection with bilateral optic neuritis and intracerebral demyelinization lesions].in september, 1987, the authors saw a 25-year-old female patient with retinal perivasculitis, cystoid macular edema and papilledema in her right eye. the left eye was normal. visual acuity was 0.2 (od), 1.2 (os). after conventional infections had been ruled out systemic methylprednisolone therapy was instituted, but the patient's condition deteriorated. in may 1988 she presented with papilledema and a "neuroretinitis"-like finding in her left eye; in her right eye advanced optic nerve atrophy; v ...19892796241
[acute borrelia burgdorferi encephalitis (lyme disease) in an algerian child].a case of acute hemorrhagic leukoencephalitis is described in an algerian child with renal insufficiency that had been diagnosed at the terminal stage. convulsions, hemiplegia and consciousness disorders pointed to a necrotizing viral or bacterial form of encephalitis, but the definitive diagnosis was based on the detection of igm and igg specific serum antibodies raised against borrelia burgdorferi.19892798000
[lyme disease in belgium: presence of the spirochete borrelia burgdorferi in ixodes ricinus ticks recovered from the meuse river region]. 19892799146
enzootic transmission of the agent of lyme disease in determine whether cottontail rabbits (sylvilagus floridanus) maintain an enzootic cycle of transmission of the lyme disease spirochete (borrelia burgdorferi), we examined the prevalence of infection in ticks and rabbits in a location in which rabbits were abundant. of 72 unfed nymphal ixodes dentatus swept from vegetation, 32% were infected by this spirochete, as determined by darkfield microscopy and indirect immunofluorescence using monoclonal antibody h5332. infected ticks were reared from ...19892802026
antibody response in white-footed mice (peromyscus leucopus) experimentally infected with the lyme disease spirochete (borrelia burgdorferi).white-footed mice (peromyscus leucopus), the primary reservoir for borrelia burgdorferi in the northern midwest and northeastern united states, were experimentally inoculated with an infectious strain or a noninfectious strain of the lyme disease spirochete and examined for their specific antibody response with the enzyme-linked immunosorbent assay and western blot (immunoblot) analysis. immunoglobulin m (igm) anti-b. burgdorferi antibodies were detected in mice 1 to 2 days after inoculation wit ...19892807530
biochemical and immunological characterization of the surface proteins of borrelia burgdorferi.the immunodominant proteins and glycoproteins of borrelia burgdorferi were analyzed by one-dimensional (1d) and 2d gel electrophoresis. more than 100 polypeptide species could be detected on silver-stained 2d gels. separation of sonic extracts of the organism by differential centrifugation (100,000 x g) revealed several of the major proteins to reside predominantly within the pellet fraction. the antigenicity of the individual polypeptides was determined by western (immuno-) blot analysis with s ...19892807540
the risk of borrelia burgdorferi infection is not increased in pet owners. 19892810640
dermatologic manifestations of lyme disease.erythema migrams (em), the distinctive cutaneous lesion of lyme disease, has a variable clinical appearance, but at some point presents as a centrifugally expanding, usually erythematous, annular patch. of 237 patients with this condition, 201 (85%) were examined initially from may through september. thirty-four (14%) remembered having been bitten by a deer tick. the median interval from the bite to the appearance of em was 9 days (range, 1-36 days). forty-one (17%) of the patients had multiple ...19892814169
clinical pathologic correlations of lyme disease.the multisystem effects caused by borrelia burgdorferi in lyme disease are multiple, varied, and unpredictable. in some patients, the full extent of the infection consists of a stage i acute systemic viral-like illness. stage ii primarily involves the cardiovascular system (myocarditis) and/or the central nervous system (cns) (meningoencephalitis, polyradiculitis). more inflammatory cells are found in the heart and nervous system structures during this intermediate stage than are found in any ti ...19892814170
immunochemical characterization of and isolation of the gene for a borrelia burgdorferi immunodominant 60-kilodalton antigen common to a wide range of crossed immunoelectrophoresis and western blotting (immunoblotting), it was shown that borrelia burgdorferi expresses the 60-kilodalton common antigen (ca) that is cross-reactive with an equivalent antigen in a wide range of remotely related bacteria. b. burgdorferi ca is strongly immunogenic. a b. burgdorferi genomic library was constructed by using a plasmid cloning system. escherichia coli recombinants were screened for expression of immunodominant b. burgdorferi antigens. one of the recom ...19882840400
borrelia burgdorferi infection: a neurologist's perspective. 19882847620
differences between lyme disease and european arthropod-borne borrelia infections. 19852857456
meningoradiculitis associated with infection by borrelia burgdorferi. 19852861356
lyme disease in patients previously suspected of arbovirus infection. 19852861536
meningoradiculitis associated with infections by borrelia burgdorferi. 19852862333
serology of lyme disease. 19862869276
myocarditis associated with tickborne borrelia burgdorferi infection. 19862872445
the etiologic agent of lyme disease in deer flies, horse flies, and mosquitoes. 19862873190
multiple sclerosis and borrelia burgdorferi. 19862875306
reinfection with borrelia burgdorferi. 19862877167
spirochaetes and lyme disease. 19862877362
emerging pattern of lyme disease in the united kingdom and irish the past year there have been 68 cases of lyme disease in the united kingdom and republic of ireland. 41 patients had erythema chronicum migrans, and 8 of them had associated neurological disease. 13 further patients presented with neurological disease without a preceding skin lesion. myocarditis was present in 1 patient. ixodes ricinus was confirmed as the vector for lyme disease. in two areas deer were found to be infected by borrelia burgdorferi, the causative organism of lyme disease. 86% ...19872880076
antibodies to borrelia burgdorferi and localised scleroderma. 19872882098
horse reservoir for borrelia burgdorferi? 19872882362
shulman syndrome, a scleroderma subtype caused by borrelia burgdorferi? 19872885476
lyme disease in europe. 19872886728
borrelia burgdorferi antibodies and amyotrophic lateral sclerosis. 19872886788
borrelia burgdorferi and shulman syndrome. 19872887905
potential for exposure to tick bites in recreational parks in a lyme disease endemic area.eight recreational parks located in a lyme disease endemic area of southern new york state were surveyed for the presence of ticks during the summer of 1985 by drag sampling. ixodes dammini, the primary vector of lyme disease in the northeast, was found in all but one park and accounted for 580 (91.8 per cent) of the 632 ticks collected. of these, 18 per cent were larvae, 80 per cent were nymphs, and 2 per cent were adults. an i. dammini encounter distance, defined as the mean number of meters t ...19892909174
enzyme-linked immunosorbent assays for lyme disease: reactivity of subunits of borrelia burgdorferi.we prepared fractions of borrelia burgdorferi, the etiologic agent of lyme disease, from cultured spirochetes and used them as antigen in an enzyme-linked immunosorbent assay (elisa) for igg antibody. polystyrene plates coated with an extract containing major proteins with apparent molecular masses of 34, 39, 59, and 68 kilodaltons had comparable sensitivity but greater specificity than plates coated with whole cells. of the 33 serum specimens from individuals with lyme disease that reacted with ...19892909642
spirochetes in the spleen of a patient with chronic lyme disease.a 54-year-old man had intermittent evening fever, arthralgia, transient erythematous macular eruption on the skin, and splenomegaly of two year's duration. immunofluorescence tests for borrelia burgdorferi serum antibodies had positive results, but g-penicillin treatment was ineffective. splenectomy with lymph node biopsy was performed to rule out lymphoproliferative disorders. borrelia-like spirochetes were identified histologically in the spleen; this finding was consistent with persistence of ...19892910019
rapid emergence of a focal epidemic of lyme disease in coastal massachusetts.we describe a focal epidemic of lyme disease, which spread from a nature preserve and affected an adjacent community of permanent residents in coastal massachusetts. the attack rate from 1980 through 1987 was 35 percent among 190 residents living within 5 km of the nature preserve and was greatest (66 percent) among those living closest to the preserve. the risk of infection bore little relation to sex or age. late lyme disease, which clustered near the preserve, occurred mainly in residents inf ...19892911294
increased risk of lyme disease for cat owners. 19892911299
lack of antibodies to borrelia burgdorferi in patients with amyotrophic lateral sclerosis. 19892911315
antigenically variable borrelia burgdorferi isolated from cottontail rabbits and ixodes dentatus in rural and urban areas.spirochetes were isolated from 71 subadult ixodes dentatus removed from cottontail rabbits captured in millbrook, n.y., and in new york, n.y. spirochetes were also cultured from kidney tissues of six rabbits. while all isolates reacted with monoclonal antibody h9724, which identifies the spirochetes as borreliae, more than half did not bind with antibody h5332 and even fewer reacted with h3ts, both of which were produced to outer surface protein a of borrelia burgdorferi. sodium dodecyl sulfate- ...19892913024
detection of antigens in urine of mice and humans infected with borrelia burgdorferi, etiologic agent of lyme disease.lyme disease is a seasonal tick-borne malady which has worldwide distribution. early and accurate diagnosis of lyme disease is essential for successful antibiotic therapy. symptoms are too vague to make an early diagnosis based on conventional criteria. we report the detection of antigens of borrelia burgdorferi, causative agent of lyme disease, in the urine of infected mice and humans. this technique may eventually provide a rapid diagnostic test for the early and accurate detection of this ill ...19892913036
borrelia burgdorferi and localized scleroderma. 19892913967
adult ixodes dammini on rabbits: development of acute inflammation in the skin and immune responses to salivary gland, midgut, and spirochetal components.rabbits exposed to female ixodes dammini (both uninfected and infected with borrelia burgdorferi) or injected with b. burgdorferi showed an acute inflammatory response in the skin. granulocytes and monocyte-histiocytes were the predominant infiltrating cells. spirochetes were detected in the tick feeding cavities in the deep dermis. the inflammatory process was accompanied by polyclonal antibody responses to tick salivary gland components. western blots showed that immune rabbit serum reacted wi ...19892915155
an outbreak of ehrlichiosis in members of an army reserve unit exposed to outbreak of unexplained illness occurred in members of an army reserve unit after field training in an area of new jersey endemic for lyme disease. nine (12%) of the 74 who attended the exercise had serological evidence of ehrlichia infection, defined as a single rise in titer of antibody to ehrlichia canis greater than or equal to 1:160 four weeks after training. two reservists with early serum samples had documented seroconversion, defined by a four-fold or greater increase in titer of anti ...19892915168
incompetence of catbirds as reservoirs for the lyme disease spirochete (borrelia burgdorferi).we compared the relative infectivity to vector ticks of gray catbirds (dumetella carolinensis) and white-footed mice (peromyscus leucopus) for the lyme disease spirochete (borrelia burgdorferi). of 28 catbirds captured in a site enzootic for this agent, 18 were infested by immature ixodes dammini, the tick vector. by comparison, each of 32 mice sampled concurrently from the same site was infested, and by about 10 times as many ticks as were found infesting the 3 most commonly netted bird species ...19892918445
[intestinal spirochetes].we report a case of intestinal spirochaetosis. the bacteria were seen by light microscopy and reacted in an indirect immunofluorescence test on the biopsy material with serum with high levels of igg antibodies against borrelia burgdorferi. the patient's own serum had no detectable antibody activity against the bacteria. no inflammatory response was observed. aspects of these findings are discussed.19892919380
infants born to mothers with antibodies against borrelia burgdorferi at delivery.a serological survey over a 1-year period of 1416 mothers at delivery and their 1434 offspring for the presence of anti-borrelia burgdorferi antibodies revealed a prevalence of 0.85%. clinically active lyme disease during pregnancy was found in 1 of these 12 women with elevated titres and the child was born with a ventricular septal defect. of six affected children, two had hyperbilirubinaemia, one muscular hypotonia, one was underweight for gestational age, one was macrocephalic, and one had su ...19892920747
meningitis due to borrelia burgdorferi in the initial stage of lyme disease.borrelia burgdorferi (b.b.) was isolated from cerebrospinal fluid from two children with aseptic meningitis. serology for b.b. was initially negative or borderline and became positive during the subsequent course. children with aseptic meningitis of unknown origin should be re-evaluated within 1 month to detect possible increasing antibody titres to b.b. aseptic meningitis may be a stage 1 manifestation of lyme disease.19892920748
interaction of lyme disease spirochetes with cultured eucaryotic cells.the association of the lyme disease spirochete, borrelia burgdorferi, with cultured human endothelial cells was investigated. attachment was time and temperature dependent, with optimal adherence occurring after 4 h of incubation at 37 degrees c. pretreatment of borreliae with heat, immune human serum, or monoclonal antibodies directed against outer surface protein b (ospb) reduced the attachment of organisms to host cell monolayers. these results suggest that the adherence of b. burgdorferi may ...19892925254
borrelia burgdorferi attachment to mammalian cells. 19892926175
prevalence of borrelia burgdorferi in ixodes ricinus ticks in berlin (west).in 1986, 1711 nymphal and adult ixodes ricinus orginating from berlin (west) forests were examined individually or in pools of up to 10 ticks for the presence of borrelia burgdorferi, the etiologic agent of lyme borreliosis. detection of borreliae was carried out by means of a culture method using modified barbour-stoenner-kelly-medium (bsk ii). tick populations from 14 out of 15 locations contained positive specimens. the calculated minimal infection rate of pooled ticks was 2.5% in nymphs (n = ...19892929194
[lyme disease without arthritis: presence of antiborrelia burgdorferi antibodies in meningoradiculitis following chronic erythema migrans]. 19852931689
[lyme disease: 2 new cases confirmed serologically]. 19852933718
proliferative responses of mononuclear cells in lyme disease. reactivity to borrelia burgdorferi antigens is greater in joint fluid than in 27 patients with early lyme disease, the mean response of peripheral blood mononuclear cells (pbmc) to lyme spirochetal borrelia burgdorferi antigens (723 counts per minute) was similar to that of control subjects. during convalescence, 2-3 weeks later, the patients' mean response was significantly higher (2,075 cpm, p less than 0.008). compared with those with early disease, the pbmc of 22 patients with lyme arthritis reacted even more to b burgdorferi (2,923 cpm, p less than 0.0004), and, b ...19862941022
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