Publications

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hemoglobin biosynthesis in vitreoscilla stercoraria dw: cloning, expression, and characterization of a new homolog of a bacterial globin gene.in the strictly aerobic, gram-negative bacterium vitreoscilla strain c1, oxygen-limited growth conditions create a more than 50-fold increase in the expression of a homodimeric heme protein which was recognized as the first bacterial hemoglobin (hb). the recently determined crystal structure of vitreoscilla hb has indicated that the heme pocket of microbial globins differs from that of eukaryotic hbs. in an attempt to understand the diverse functions of hb-like proteins in prokaryotes, we have c ...19989603838
production of superoxide anions by keratinocytes initiates p. acnes-induced inflammation of the skin.acne vulgaris is a chronic inflammatory disorder of the sebaceous follicles. propionibacterium acnes (p. acnes), a gram-positive anareobic bacterium, plays a critical role in the development of these inflammatory lesions. this study aimed at determining whether reactive oxygen species (ros) are produced by keratinocytes upon p. acnes infection, dissecting the mechanism of this production, and investigating how this phenomenon integrates in the general inflammatory response induced by p. acnes. i ...200919629174
a new vitreoscilla filiformis extract grown on spa water-enriched medium activates endogenous cutaneous antioxidant and antimicrobial defenses through a potential toll-like receptor 2/protein kinase c, zeta transduction pathway.vitreoscilla filiformis (vf) biomass (vfb) has been widely used in cosmetic preparations and shown to modulate the major inducible free-radical scavenger mitochondrial superoxide dismutase in skin cells. by adding la roche-posay (lrp) thermal spring water to the vf culture medium, we obtained a biomass (lrp-vfb) with a similar mitochondrial superoxide dismutase activation capacity to vf. also, the new biomass more powerfully stimulated mrna expression and antimicrobial peptides in reconstructed ...201324039440
regulation of t cell immunity in atopic dermatitis by microbes: the yin and yang of cutaneous inflammation.atopic dermatitis (ad) is a chronic inflammatory skin disease predominantly mediated by t helper cells. while numerous adaptive immune mechanisms in ad pathophysiology have been elucidated in detail, deciphering the impact of innate immunity in ad pathogenesis has made substantial progress in recent years and is currently a fast evolving field. as innate and adaptive immunity are intimately linked, cross-talks between these two branches of the immune system are critically influencing the resulti ...201526217343
barrier function and microbiotic dysbiosis in atopic dermatitis.atopic dermatitis (ad) or atopic eczema is the common inflammatory skin disorder, the prevalence of which has considerably increased during the last 30 years. it affects 15%-30% of children and 2%-10% of adults. ad characteristically alternates between periods of exacerbation or flares and periods of remission, which may be therapeutically induced or spontaneous. current knowledge about ad includes abnormalities of the skin barrier (physical and chemical), the immune barrier, and more recently, ...201526396539
non-pathogenic microflora of a spring water with regenerative properties.the comano spring water (comano, italy) has been demonstrated to improve skin regeneration, not only by increasing keratinocyte proliferation and migration, but also by modulating the regenerated collagen and elastic fibers in the dermis. however, such biological properties may not be entirely explained by its mineral composition only. as the non-pathogenic bacterial populations have demonstrated an active role in different biological processes, the potential presence of non-pathogenic bacterial ...201526623012
transplantation of human skin microbiota in models of atopic dermatitis.atopic dermatitis (ad) is characterized by reduced barrier function, reduced innate immune activation, and susceptibility to staphylococcus aureus. host susceptibility factors are suggested by monogenic disorders associated with ad-like phenotypes and can be medically modulated. s. aureus contributes to ad pathogenesis and can be mitigated by antibiotics and bleach baths. recent work has revealed that the skin microbiome differs significantly between healthy controls and patients with ad, includ ...201627478874
novel perspectives on the role of the human microbiota in regenerative medicine and surgery.plastic surgery is transitioning from a fine craftsmanship to a regenerative science. in wound healing, the role of microorganisms is no longer considered to be just counteracting, but also promoting. furthermore, host-microbe interactions are essential for numerous aspects of normal mammalian physiology, from metabolic activity to immune homeostasis. each area of the human body hosts a unique microbial community, and the composition of microbiota is dependent on the host, age and the anatomical ...201627882211
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