| la crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys. | la crosse virus (lacv), family bunyaviridae, was first identified as a human pathogen in 1960 after its isolation from a 4 year-old girl with fatal encephalitis in la crosse, wisconsin. lacv is a major cause of pediatric encephalitis in north america and infects up to 300,000 persons each year of which 70-130 result in severe disease of the central nervous system (cns). as an initial step in the establishment of useful animal models to support vaccine development, we examined lacv infectivity, p ... | 2008 | 18267012 |
| A Recombinant Chimeric La Crosse Virus Expressing the Surface Glycoproteins of Jamestown Canyon Virus Is Immunogenic and Protective against Challenge with either Parental Virus in Mice or Monkeys. | La Crosse virus (LACV) and Jamestown Canyon virus (JCV), family Bunyaviridae, are mosquito-borne viruses that are endemic in North America and recognized as etiologic agents of encephalitis in humans. Both viruses belong to the California encephalitis virus serogroup, which causes 70 to 100 cases of encephalitis a year. As a first step in creating live attenuated viral vaccine candidates for this serogroup, we have generated a recombinant LACV expressing the attachment/fusion glycoproteins of JC ... | 2012 | 22013033 |
| tahyna virus genetics, infectivity, and immunogenicity in mice and monkeys. | tahyna virus (tahv) is a human pathogen of the california encephalitis virus (cev) serogroup (bunyaviridae) endemic to europe, asia, and africa. tahv maintains an enzootic life cycle with several species of mosquito vectors and hares, rabbits, hedgehogs, and rodents serving as small mammal amplifying hosts. human tahv infection occurs in summer and early fall with symptoms of fever, headache, malaise, conjunctivitis, pharyngitis, and nausea. tahv disease can progress to cns involvement, although ... | 2011 | 21435229 |