characterization and pathogenesis of aerosolized eastern equine encephalitis in the common marmoset (callithrix jacchus).licensed antiviral therapeutics and vaccines to protect against eastern equine encephalitis virus (eeev) in humans currently do not exist. animal models that faithfully recapitulate the clinical characteristics of human eeev encephalitic disease, including fever, drowsiness, anorexia, and neurological signs such as seizures, are needed to satisfy requirements of the food and drug administration (fda) for clinical product licensing under the animal rule.201728173871
common marmosets (callithrix jacchus) as a nonhuman primate model to assess the virulence of eastern equine encephalitis virus strains.eastern equine encephalitis virus (eeev) produces the most severe human arboviral disease in north america (na) and is a potential biological weapon. however, genetically and antigenically distinct strains from south america (sa) have seldom been associated with human disease or mortality despite serological evidence of infection. because mice and other small rodents do not respond differently to the na versus sa viruses like humans, we tested common marmosets (callithrix jacchus) by using intra ...200818614636
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