coronavirus isolates sk and sd from multiple sclerosis patients are serologically related to murine coronaviruses a59 and jhm and human coronavirus oc43, but not to human coronavirus 229e.two coronaviruses (sk and sd), isolated from fresh autopsy brain tissue from two multiple sclerosis patients, were compared with known human and murine coronaviruses. in plaque neutralization assays, antisera prepared against multiple sclerosis isolates sk and sd demonstrated significant cross-reactivity to each other and to murine coronavirus a59, weak cross-reactivity to murine coronavirus jhm, but no cross-reactivity to the human coronavirus 229e. antiserum to sk or sd failed to inhibit hemag ...19817241654
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