| molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. | massive numbers of palm civets were culled to remove sources for the reemergence of severe acute respiratory syndrome (sars) in guangdong province, china, in january 2004, following sars coronavirus detection in market animals. the virus was identified in all 91 palm civets and 15 raccoon dogs of animal market origin sampled prior to culling, but not in 1,107 palm civets later sampled at 25 farms, spread over 12 provinces, which were claimed to be the source of traded animals. twenty-seven novel ... | 2005 | 16140765 |
| wet markets--a continuing source of severe acute respiratory syndrome and influenza? | context: live-animal markets (wet markets) provide a source of vertebrate and invertebrate animals for customers in tropical and subtropical regions of the world. wet markets sell live poultry, fish, reptiles, and mammals of every kind. live-poultry markets (mostly chicken, pigeon, quail, ducks, geese, and a wide range of exotic wild-caught and farm-raised fowl) are usually separated from markets selling fish or red-meat animals, but the stalls can be near each other with no physical separation. ... | 2004 | 14738798 |
| synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. | the severe acute respiratory syndrome (sars) epidemic was characterized by high mortality rates in the elderly. the molecular mechanisms that govern enhanced susceptibility of elderly populations are not known, and robust animal models are needed that recapitulate the increased pathogenic phenotype noted with increasing age. using synthetic biology and reverse genetics, we describe the construction of a panel of isogenic sars coronavirus (sars-cov) strains bearing variant spike glycoproteins tha ... | 2007 | 17507479 |
| isolation and characterization of viruses related to the sars coronavirus from animals in southern china. | a novel coronavirus (scov) is the etiological agent of severe acute respiratory syndrome (sars). scov-like viruses were isolated from himalayan palm civets found in a live-animal market in guangdong, china. evidence of virus infection was also detected in other animals (including a raccoon dog, nyctereutes procyonoides) and in humans working at the same market. all the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. the detection of scov-like viruses in ... | 2003 | 12958366 |
| [detection of sars-coronavirus in both human and animals by rt-pcr]. | to find the most suitable rt-pcr detection method for sars-coronavirus (sars-cov) detection in both human and animals, and to study the source of sars virus by investigating the condition of virus carried by wild, domestic animals and animals sold in market. | 2005 | 16229261 |
| tracing the sars-coronavirus. | four coronaviruses (hcov-229e, hcov-oc43, hcov-nl63, hcov-hku1) are endemic in humans and mainly associated with mild respiratory illnesses; whereas the other two coronaviruses [severe acute respiratory syndrome coronavirus (sars-cov) and middle east respiratory syndrome coronavirus (mers-cov)] present as emerging infections causing severe respiratory syndrome. coronaviruses evolve by accumulation of point mutations and recombination of genomes among different strains or species. mammalian coron ... | 2013 | 23977431 |