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chinese hamster ovary cell lines selected for resistance to ebolavirus glycoprotein mediated infection are defective for npc1 expression.ebolavirus causes severe hemorrhagic fever in humans and non-human primates. entry of ebolavirus is mediated by the viral glycoprotein, gp; however, the required host factors have not been fully elucidated. a screen utilizing a recombinant vesicular stomatitis virus (vsv) encoding zaire ebolavirus gp identified four chinese hamster ovary (cho) cell lines resistant to gp-mediated viral entry. susceptibility to vectors carrying sars coronavirus s or vsv-g glycoproteins suggests that endocytic and ...201222726751
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