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a guinea pig model of zika virus infection.animal models are critical to understand disease and to develop countermeasures for the ongoing epidemic of zika virus (zikv). here we report that immunocompetent guinea pigs are susceptible to infection by a contemporary american strain of zikv.201728399888
intranasal infection and contact transmission of zika virus in guinea pigs.zika virus (zikv) is primarily transmitted to humans through mosquito bites or sexual contact. the excretion and persistence of contagious zikv in various body fluids have been well documented in zikv patients; however, the risk of direct contact exposure remains unclear. here, we show that guinea pigs are susceptible to zikv infection via subcutaneous inoculation route; infected guinea pigs exhibit seroconversion and significant viral secretion in sera, saliva, and tears. notably, zikv is effic ...201729162827
assessing zika virus replication and the development of zika-specific antibodies after a mid-gestation viral challenge in guinea pigs.primary zika virus (zikv) infections that occur during pregnancy can cause spontaneous abortion and profoundly disrupt fetal development. while the full range of developmental abnormalities associated with congenital zika syndrome is not yet known, severe cases of the syndrome can present with microcephaly, extensive neurologic and ocular damage, and pronounced joint malformations. animal models that accurately recapitulate congenital zika syndrome are urgently needed for vaccine development and ...201729099873
route of infection influences zika virus shedding in a guinea pig model.due to the recent epidemic of zika virus (zikv) infection and resulting sequelae, as well as concerns about both the sexual and vertical transmission of the virus, renewed attention has been paid to the pathogenesis of this unique arbovirus. numerous small animal models have been used in various zikv pathogenicity studies, however, they are often performed using immunodeficient or immunosuppressed animals, which may impact disease progression in a manner not relevant to immunocompetent humans. t ...201931739508
in vitro and in vivo models for studying zika virus biology.the emergence and rapid spread of zika virus (zikv) in the americas has prompted the development of in vitro and in vivo models to understand several aspects of zikv biology and boost the development of vaccines and antivirals. in vitro model studies include reverse genetics systems, two-dimensional (2d) cell models, such as primary cells and cell lines, and ex vivo three-dimensional (3d) models derived from skin, brain and placenta. while these models are cost-effective and allow rigorous contr ...201830325302
animal models of congenital zika syndrome provide mechanistic insight into viral pathogenesis during pregnancy.in utero zika virus (zikv; family flaviviridae) infection causes a distinct pattern of birth defects and disabilities in the developing fetus and neonate that has been termed congenital zika syndrome (czs). over 8,000 children were affected by the 2016 to 2017 zikv outbreak in the americas, many of whom developed czs as a result of in utero exposure. to date, there is no consensus about how zikv causes czs; animal models, however, are providing mechanistic insights. using nonhuman primates, immu ...202033091001
zika virus and host interactions: from the bench to the bedside and beyond.before the emergence of sars-cov-2 (severe acute respiratory syndrome coronavirus 2), the causative agent of the current covid-19 (coronavirus disease 2019) pandemic [...].202033198165
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