zika virus infection in syrian golden hamsters and strain 13 guinea evaluate potential immunocompetent small animal models of zika virus (zikv) infection, we inoculated syrian golden hamsters (subcutaneously or intraperitoneally) and strain 13 guinea pigs (intraperitoneally) with senegalese zikv strain ard 41525 or philippines zikv strain cpc-0740. we did not detect viremia in hamsters inoculated subcutaneously with either virus strain, although some hamsters developed virus neutralizing antibodies. however, we detected statistically significant higher viremi ...201829405107
a combination of tlr-4 agonist and saponin adjuvants increases antibody diversity and protective efficacy of a recombinant west nile virus antigen.members of the flaviviridae family are the leading causes of mosquito-borne viral disease worldwide. while dengue virus is the most prevalent, the recent zika virus outbreak in the americas triggered a who public health emergency, and yellow fever and west nile viruses (wnv) continue to cause regional epidemics. given the sporadic nature of flaviviral epidemics both temporally and geographically, there is an urgent need for vaccines that can rapidly provide effective immunity. protection from fl ...201830302281
human polyclonal antibodies produced from transchromosomal bovine provides prophylactic and therapeutic protections against zika virus infection in stat2 ko syrian hamsters.zika virus (zikv) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and guillainā»barré syndrome in adults. efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating zikv infection. here, we report that zikv-specific human polyclonal antibodies (sab-155), elicited in transchromosomal bovine (tcb), provide significant protection from infection by z ...201930678320
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