Publications

translational model of zika virus disease in baboons.	zika virus (zikv) is an emerging mosquito-borne flavivirus with devastating outcomes seen recently in the americas due to the association of maternal zikv infection with fetal microcephaly and other fetal malformations not previously associated with flavivirus infections. here, we have developed the olive baboon (papio anubis) as a nonhuman primate (nhp) translational model for the study of zikv pathogenesis and associated disease outcomes to contrast and compare with humans and other major nhps ...	2018	29875247
zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon.	zika virus (zikv) infection during pregnancy in humans is associated with an increased incidence of congenital anomalies including microcephaly as well as fetal death and miscarriage and collectively has been referred to as congenital zika syndrome (czs). animal models for zikv infection in pregnancy have been developed including mice and non-human primates (nhps). in macaques, fetal czs outcomes from maternal zikv infection range from none to significant. in the present study we develop the oli ...	2019	30657788
zika virus infection, reproductive organ targeting, and semen transmission in the male olive baboon.	zika virus (zikv) infection in pregnant women is a serious threat to the development and viability of the fetus. the primary mode of zikv transmission to humans is through mosquito bites, but sexual transmission has also been well documented in humans. however, little is known of the short- and long-term effects of zikv infection on the human male reproductive system. this study examines the effects of zikv infection on the male reproductive organs and semen and the immune response of the olive ...	2019	31597777
maternal zika virus (zikv) infection following vaginal inoculation with zikv-infected semen in timed-pregnant olive baboons.	zika virus (zikv) infection is now firmly linked to congenital zika syndrome (czs), including fetal microcephaly. while aedes species of mosquito are the primary vector for zikv, sexual transmission of zikv is a significant route of infection. zikv has been documented in human, mouse, and nonhuman primate (nhp) semen. it is critical to establish nhp models of the vertical transfer of zikv that recapitulate human pathogenesis. we hypothesized that vaginal deposition of zikv-infected baboon semen ...	2020	32188737