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zika virus infection in tupaia belangeri causes dermatological manifestations and confers protection against secondary infection.animal models of zika virus (zikv) infection have recently been established in mice, guinea pigs, and nonhuman primates. tree shrews (tupaia belangeri) are an emerging experimental animal in biomedical applications, but their susceptibility to zikv infection has not been explored. in the present study, we show that subcutaneous inoculation of zikv led to rapid viremia and viral secretion in saliva, as well as to typical dermatological manifestations characterized by massive diffuse skin rash on ...201930728253
development and characterization of double-antibody sandwich elisa for detection of zika virus infection.zika virus (zikv) is an emerging mosquito-transmitted flavivirus that can cause severe disease, including congenital birth defect and guillain-barré syndrome during pregnancy. although, several molecular diagnostic methods have been developed to detect the zikv, these methods pose challenges as they cannot detect early viral infection. furthermore, these methods require the extraction of rna, which is easy to contaminate. nonstructural protein 1 (ns1) is an important biomarker for early diagnosi ...201830445676
recapitulating zika virus infection in vagina of tree shrew (tupaia belangeri).sexual transmission of zika virus (zikv) elevates the risk of its dissemination in the female reproductive tract and causes a serious threat to the fetus. however, the available animal models are not appropriate to investigate sexual transmission, dynamics of zikv infection, replication, and shedding. the use of tree shrew as a small animal model of zikv vaginal infection was assessed in this study. a total of 23 sexually mature female tree shrews were infected with zikv gz01 via the intravagina ...202134249779
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