dual interference with novel genes mfgl2 and mtnfr1 ameliorates murine hepatitis virus type 3-induced fulminant hepatitis in balb/cj mice.our studies and those of many others have implicated hepatocyte necrosis and apoptosis mediated by fibrinogen-like protein-2 (fgl2) prothrombinase and tumor necrosis factor receptor (tnfr) in the development of fulminant viral hepatitis, a disease with a mortality rate greater than 80% in cases lacking immediate organ transplantation. this study was designed to explore the efficacy of dual short hairpin rna (shrna) interference with fgl2 and tnfr1 in the treatment of murine hepatitis virus strai ...201020218879
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