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receptor tyrosine kinase inhibitors block proliferation of tgev mainly through p38 mitogen-activated protein kinase pathways.emerging coronaviruses (covs) primarily cause severe gastroenteric or respiratory diseases in humans and animals, and no approved therapeutics are currently available. here, a9, a receptor tyrosine kinase inhibitor (rtki) of the tyrphostin class, is identified as a robust inhibitor of transmissible gastroenteritis virus (tgev) infection in cell-based assays. moreover, a9 exhibited potent antiviral activity against the replication of various covs, including murine hepatitis virus (mhv), porcine e ...202031751591
structural basis of sars-cov-2 main protease inhibition by a broad-spectrum anti-coronaviral drug.the coronavirus disease 2019 (covid-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) or 2019 novel coronavirus (2019-ncov), took tens of thousands of lives and caused tremendous economic losses. the main protease (mpro) of sars-cov-2 is a potential target for treatment of covid-19 due to its critical role in maturation of viral proteins and subsequent viral replication. conceptually and technically, targeting therapy against mpro is similar to target therapy t ...202032905393
plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.we describe the antiviral activity of plant lectins with specificity for different glycan structures against the severe acute respiratory syndrome coronavirus (sars-cov) and the feline infectious peritonitis virus (fipv) in vitro. the sars-cov emerged in 2002 as an important cause of severe lower respiratory tract infection in humans, and fipv infection causes a chronic and often fatal peritonitis in cats. a unique collection of 33 plant lectins with different specificities were evaluated. the p ...200717428553
mosaic evolution of the severe acute respiratory syndrome coronavirus.severe acute respiratory syndrome (sars) is a deadly form of pneumonia caused by a novel coronavirus, a viral family responsible for mild respiratory tract infections in a wide variety of animals including humans, pigs, cows, mice, cats, and birds. analyses to date have been unable to identify the precise origin of the sars coronavirus. we used bayesian, neighbor-joining, and split decomposition phylogenetic techniques on the sars virus replicase, surface spike, matrix, and nucleocapsid proteins ...200414671089
pathogenesis of coronavirus-induced infections. review of pathological and immunological aspects.coronaviruses and arteriviruses infect multiple species of mammals, including humans, causing diseases that range from encephalitis to enteritis. several of these viruses infect domestic animals and cause significant morbidity and mortality, leading to major economic losses. in this category are included such pathogens as transmissible gastroenteritis virus, porcine respiratory and reproductive virus and infectious bronchitis virus. the feline coronaviruses (fecv) generally do not cause infectio ...19989782322
two-way antigenic cross-reactivity between severe acute respiratory syndrome coronavirus (sars-cov) and group 1 animal covs is mediated through an antigenic site in the n-terminal region of the sars-cov nucleoprotein.in 2002, severe acute respiratory syndrome-associated coronavirus (sars-cov) emerged in humans, causing a global epidemic. by phylogenetic analysis, sars-cov is distinct from known covs and most closely related to group 2 covs. however, no antigenic cross-reactivity between sars-cov and known covs was conclusively and consistently demonstrated except for group 1 animal covs. we analyzed this cross-reactivity by an enzyme-linked immunosorbent assay (elisa) and western blot analysis using specific ...200717913799
feline aminopeptidase n is not a functional receptor for avian infectious bronchitis virus.coronaviruses are an important cause of infectious diseases in humans, including severe acute respiratory syndrome (sars), and have the continued potential for emergence from animal species. a major factor in the host range of a coronavirus is its receptor utilization on host cells. in many cases, coronavirus-receptor interactions are well understood. however, a notable exception is the receptor utilization by group 3 coronaviruses, including avian infectious bronchitis virus (ibv). feline amino ...200717324273
atp1a1-mediated src signaling inhibits coronavirus entry into host cells.in addition to transporting ions, the multisubunit na(+),k(+)-atpase also functions by relaying cardiotonic steroid (cts)-binding-induced signals into cells. in this study, we analyzed the role of na(+),k(+)-atpase and, in particular, of its atp1a1 α subunit during coronavirus (cov) infection. as controls, the vesicular stomatitis virus (vsv) and influenza a virus (iav) were included. using gene silencing, the atp1a1 protein was shown to be critical for infection of cells with murine hepatitis v ...201525653449
crystal structure of feline infectious peritonitis virus main protease in complex with synergetic dual inhibitors.coronaviruses (covs) can cause highly prevalent diseases in humans and animals. feline infectious peritonitis virus (fipv) belongs to the genus alphacoronavirus, resulting in a lethal systemic granulomatous disease called feline infectious peritonitis (fip), which is one of the most important fatal infectious diseases of cats worldwide. no specific vaccines or drugs have been approved to treat fip. cov main proteases (m(pro)s) play a pivotal role in viral transcription and replication, making th ...201526656689
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