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in vitro hepatic metabolism of mefloquine using microsomes from cats, dogs and the common brush-tailed possum (trichosurus vulpecula).feline infectious peritonitis (fip) is a systemic, fatal, viral-induced, immune-mediated disease of cats caused by feline infectious peritonitis virus (fipv). mefloquine, a human anti-malarial agent, has been shown to inhibit fipv in vitro. as a first step to evaluate its efficacy and safety profile as a potential fip treatment for cats, mefloquine underwent incubation in feline, canine and common brush-tailed possum microsomes and phase i metabolism cofactors to determine its rate of phase i de ...202032287278
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