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cryo-electron microscopy structure of the swine acute diarrhea syndrome coronavirus spike glycoprotein provides insights into evolution of unique coronavirus spike proteins.coronaviruses (cov) have caused a number of major epidemics in humans and animals, including the current pandemic of coronavirus disease 2019 (covid-19), which has brought a renewed focus on the evolution and interspecies transmission of coronaviruses. swine acute diarrhea syndrome coronavirus (sads-cov), which was recently identified in piglets in southern china, is an alphacoronavirus that originates from the same genus of horseshoe bats as severe acute respiratory syndrome cov (sars-cov) and ...202032817223
molecular diversity of coronavirus host cell entry receptors.coronaviruses are a group of viruses causing disease in a wide range of animals including humans. since 2002, the successive emergence of bat-borne severe acute respiratory syndrome coronavirus (sars-cov), middle east respiratory syndrome coronavirus (mers-cov), swine acute diarrhea syndrome coronavirus (sads-cov) and sars-cov-2 have reinforced efforts in uncovering the molecular and evolutionary mechanisms governing coronavirus cell tropism and interspecies transmission. decades of studies have ...202033118022
broad cross-species infection of cultured cells by bat hku2-related swine acute diarrhea syndrome coronavirus and identification of its replication in murine dendritic cells in vivo highlight its potential for diverse interspecies transmission.outbreaks of severe diarrhea in neonatal piglets in guangdong, china, in 2017 resulted in the isolation and discovery of a novel swine enteric alphacoronavirus (seacov) derived from the species rhinolophus bat coronavirus hku2 (y. pan, x. tian, p. qin, b. wang, et al., vet microbiol 211:15-21, 2017). seacov was later referred to as swine acute diarrhea syndrome cov (sads-cov) by another group (p. zhou, h. fan, t. lan, x.-l. yang, et al., nature 556:255-258, 2018). the present study was set up to ...201931554686
increasing the translation of mouse models of mers coronavirus pathogenesis through kinetic hematological analysis.newly emerging viral pathogens pose a constant and unpredictable threat to human and animal health. coronaviruses (covs) have a penchant for sudden emergence, as evidenced by severe acute respiratory syndrome coronavirus (sars-cov), middle east respiratory syndrome cov (mers-cov) and most recently, swine acute diarrhea syndrome coronavirus (sads-cov). small animal models of emerging viral pathogenesis are crucial to better understand the virus and host factors driving disease progression. howeve ...201931339932
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