sars-cov-2 and three related coronaviruses utilize multiple ace2 orthologs and are potently blocked by an improved ace2-ig.the ongoing coronavirus disease 2019 (covid-19) pandemic has caused >20 million infections and >750,000 deaths. severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the etiological agent of covid-19, has been found closely related to the bat coronavirus strain ratg13 (bat-cov ratg13) and a recently identified pangolin coronavirus (pangolin-cov-2020). here, we first investigated the ability of sars-cov-2 and three related coronaviruses to utilize animal orthologs of angiotensin-convertin ...202032847856
are pangolins the intermediate host of the 2019 novel coronavirus (sars-cov-2)?the outbreak of a novel corona virus disease 2019 (covid-19) in the city of wuhan, china has resulted in more than 1.7 million laboratory confirmed cases all over the world. recent studies showed that sars-cov-2 was likely originated from bats, but its intermediate hosts are still largely unknown. in this study, we assembled the complete genome of a coronavirus identified in 3 sick malayan pangolins. the molecular and phylogenetic analyses showed that this pangolin coronavirus (pangolin-cov-2020 ...202032407364
identifying sars-cov-2-related coronaviruses in malayan pangolins.the ongoing outbreak of viral pneumonia in china and across the world is associated with a new coronavirus, sars-cov-21. this outbreak has been tentatively associated with a seafood market in wuhan, china, where the sale of wild animals may be the source of zoonotic infection2. although bats are probable reservoir hosts for sars-cov-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. here we report the identification of sars-cov-2-related coronavirus ...202032218527
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