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surgical mask partition reduces the risk of non-contact transmission in a golden syrian hamster model for coronavirus disease 2019 (covid-19).coronavirus disease 2019 (covid-19) caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is believed to be mostly transmitted by medium-to-large sized respiratory droplets although airborne transmission is theoretically possible in healthcare settings involving aerosol-generating procedures. exposure to respiratory droplets can theoretically be reduced by surgical mask usage. however, there is a lack of experimental evidence supporting surgical mask usage for prevention of covi ...202032472679
isolation of potent sars-cov-2 neutralizing antibodies and protection from disease in a small animal model.countermeasures to prevent and treat coronavirus disease 2019 (covid-19) are a global health priority. we enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (sars-cov-2)-recovered participants, developed neutralization assays to investigate antibody responses, adapted our high-throughput antibody generation pipeline to rapidly screen more than 1800 antibodies, and established an animal model to test protection. we isolated potent neutralizing antibodies (nabs) to two epitopes o ...202032540903
syrian hamsters as a small animal model for sars-cov-2 infection and countermeasure development.at the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; sars-cov-2) was detected in wuhan, china, that spread rapidly around the world, with severe consequences for human health and the global economy. here, we assessed the replicative ability and pathogenesis of sars-cov-2 isolates in syrian hamsters. sars-cov-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. in addition, microco ...202032571934
disruption of adaptive immunity enhances disease in sars-cov-2-infected syrian hamsters.animal models recapitulating human covid-19 disease, especially severe disease, are urgently needed to understand pathogenesis and to evaluate candidate vaccines and therapeutics. here, we develop novel severe-disease animal models for covid-19 involving disruption of adaptive immunity in syrian hamsters. cyclophosphamide (cyp) immunosuppressed or rag2 knockout (ko) hamsters were exposed to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) by the respiratory route. both the cyp-treate ...202032900822
oral sars-cov-2 inoculation establishes subclinical respiratory infection with virus shedding in golden syrian hamsters.severe acute respiratory syndrome-coronavirus 2 (sars-cov-2) is transmitted largely by respiratory droplets or airborne aerosols. despite being frequently found in the immediate environment and feces of patients, evidence supporting the oral acquisition of sars-cov-2 is unavailable. using the syrian hamster model, we demonstrate that the severity of pneumonia induced by the intranasal inhalation of sars-cov-2 increases with virus inoculum. sars-cov-2 retains its infectivity in vitro in simulated ...202032984855
pathogenesis and transmission of sars-cov-2 in golden hamsters.severe acute respiratory syndrome coronavirus 2 (sars-cov-2), a novel coronavirus with high nucleotide identity to sars-cov and to sars-related coronaviruses that have been detected in horseshoe bats, has spread across the world and had a global effect on healthcare systems and economies1,2. a suitable small animal model is needed to support the development of vaccines and therapies. here we report the pathogenesis and transmissibility of sars-cov-2 in golden (syrian) hamsters (mesocricetus aura ...202032408338
favipiravir at high doses has potent antiviral activity in sars-cov-2-infected hamsters, whereas hydroxychloroquine lacks activity.severe acute respiratory syndrome coronavirus 2 (sars-cov-2) rapidly spread around the globe after its emergence in wuhan in december 2019. with no specific therapeutic and prophylactic options available, the virus has infected millions of people of which more than half a million succumbed to the viral disease, covid-19. the urgent need for an effective treatment together with a lack of small animal infection models has led to clinical trials using repurposed drugs without preclinical evidence o ...202033037151
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