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molecular evolution and phylogenetic analysis of sars-cov-2 and hosts ace2 protein suggest malayan pangolin as intermediary host.an emergence of a novel coronavirus, causative agent of covid19, named as severe acute respiratory syndrome coronavirus 2 (sars-cov-2), occurred due to cross-species transmission. coronaviruses are a large family of viruses able to infect a great number of hosts. entrance of sars-cov-2 depends on the surface (s) protein interaction with host ace2 protein and cleavage by tmprss2. ace2 could be a species-specific barrier that interferes with bat-to-human coronavirus cross-species transmission. mol ...202032592038
an update on the origin of sars-cov-2: despite closest identity, bat (ratg13) and pangolin derived coronaviruses varied in the critical binding site and o-linked glycan residues.the initial cases of severe acute respiratory syndrome coronavirus-2 (sars-cov-2) occurred in wuhan, china, in december 2019 and swept the world by 23 june 2020 with 8 993 659 active cases, 469 587 deaths across 216 countries, areas or territories. this strongly implies global transmission occurred before the lockdown of china. however, the initial source's transmission routes of sars-cov-2 remain obscure and controversial. research data suggest bat (ratg13) and pangolin carried cov were the pro ...202032633815
isolation of sars-cov-2-related coronavirus from malayan pangolins.the current outbreak of coronavirus disease-2019 (covid-19) poses unprecedented challenges to global health1. the new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (sars-cov-2)-shares high sequence identity to sars-cov and a bat coronavirus, ratg132. although bats may be the reservoir host for a variety of coronaviruses3,4, it remains unknown whether sars-cov-2 has additional host species. here we show that a coronavirus, which we name pangolin-cov, is ...202032380510
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