Publications

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ace2 expression in the cat and the tiger gastrointestinal tracts.angiotensin-converting enzyme 2 (ace2) has been identified as the functional receptor for severe acute respiratory syndrome-coronavirus-2 (sars-cov-2). it has been identified in the human gastrointestinal tract (git), and sars-cov-2 has been isolated in human and animal fecal samples. the aim of the present study was to investigate the expression of ace2 in the gastrointestinal tract of domestic (cat) and wild (tiger) felines. samples of the pylorus, duodenum, and distal colon were collected fro ...202032903561
transmission of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) to animals: an updated review.covid-19 caused by a novel severe acute respiratory syndrome coronavirus 2 (sars-cov-2) originated in wuhan (hubei province, china) during late 2019. it has spread across the globe affecting nearly 21 million people with a toll of 0.75 million deaths and restricting the movement of most of the world population during the past 6 months. covid-19 became the leading health, economic, and humanitarian challenge of the twenty-first century. in addition to the considerable covid-19 cases, hospitalizat ...202032957995
lions, tigers and kittens too: ace2 and susceptibility to covid-19.sars-cov-2 (severe acute respiratory syndrome coronavirus 2) has been reported to infect domesticated animals in a species-specific manner, where cats were susceptible but not dogs. using the recently published crystal structure of the sars-cov-2 spike protein complexed with the human host cell receptor angiotensin converting enzyme 2 (ace2), we characterized the structure and evolution of ace2 in several of these species and identify a single interacting amino acid residue conserved between hum ...202032974030
predicting susceptibility to sars-cov-2 infection based on structural differences in ace2 across species.severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is the cause of the global pandemic of coronavirus disease-2019 (covid-19). sars-cov-2 is a zoonotic disease, but little is known about variations in species susceptibility that could identify potential reservoir species, animal models, and the risk to pets, wildlife, and livestock. certain species, such as domestic cats and tigers, are susceptible to sars-cov-2 infection, while other species such as mice and chickens are not. most ani ...202033015868
highly conserved binding region of ace2 as a receptor for sars-cov-2 between humans and mammals.several cases of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection transmitted from human owners to their dogs have recently been reported. the first ever case of sars-cov-2 transmission from a human owner to a domestic cat was confirmed on march 27, 2020. a tiger from a zoo in new york, usa, was also reportedly infected with sars-cov-2. it is believed that sars-cov-2 was transmitted to tigers from their caretakers, who were previously infected with this virus. on may 25, 20 ...202032921279
from people to panthera: natural sars-cov-2 infection in tigers and lions at the bronx zoo.despite numerous barriers to transmission, zoonoses are the major cause of emerging infectious diseases in humans. among these, severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers), and ebolaviruses have killed thousands; the human immunodeficiency virus (hiv) has killed millions. zoonoses and human-to-animal cross-species transmission are driven by human actions and have important management, conservation, and public health implications. the current sars-cov-2 pande ...202033051368
complete genome sequence of sars-cov-2 in a tiger from a u.s. zoological collection.this report describes the identification and characterization of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) in a malayan tiger in a u.s. zoo.202032467283
sars-cov-2 host diversity: an update of natural infections and experimental evidence.coronavirus disease-19 (covid-19) caused by the severe acute respiratory syndrome coronavirus-2 (sars-cov-2) is now a pandemic threat. this virus is supposed to be spread by human to human transmission. cellular angiotensin-converting enzyme 2 (ace2) is the receptor of sars-cov-2 which is identical or similar in different species of animals such as pigs, ferrets, cats, orangutans, monkeys, and humans. moreover, a recent study predicted that dogs might be secondary hosts during the evolution of s ...202032624360
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