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comparison of nonhuman primates identified the suitable model for covid-19.identification of a suitable nonhuman primate (nhp) model of covid-19 remains challenging. here, we characterized severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection in three nhp species: old world monkeys macaca mulatta (m. mulatta) and macaca fascicularis (m. fascicularis) and new world monkey callithrix jacchus (c. jacchus). infected m. mulatta and m. fascicularis showed abnormal chest radiographs, an increased body temperature and a decreased body weight. viral genomes wer ...202032814760
development of an inactivated vaccine candidate, bbibp-corv, with potent protection against sars-cov-2.the coronavirus disease 2019 (covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) threatens global public health. the development of a vaccine is urgently needed for the prevention and control of covid-19. here, we report the pilot-scale production of an inactivated sars-cov-2 vaccine candidate (bbibp-corv) that induces high levels of neutralizing antibodies titers in mice, rats, guinea pigs, rabbits, and nonhuman primates (cynomolgus monkeys and rhesus maca ...202032778225
characteristic and quantifiable covid-19-like abnormalities in ct- and pet/ct-imaged lungs of sars-cov-2-infected crab-eating macaques (macaca fascicularis).severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is causing an exponentially increasing number of coronavirus disease 19 (covid-19) cases globally. prioritization of medical countermeasures for evaluation in randomized clinical trials is critically hindered by the lack of covid-19 animal models that enable accurate, quantifiable, and reproducible measurement of covid-19 pulmonary disease free from observer bias. we first used serial computed tomography (ct) to demonstrate that bilate ...202032511338
comparative pathogenesis of covid-19, mers, and sars in a nonhuman primate model.the current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (sars-cov-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (covid-19). to compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with sars-cov-2 or middle east respiratory syndrome (mers)-cov and compared the pathology and virology with historical reports of sars-cov infections. in sars-cov-2-infected macaques, v ...202032303590
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