henipavirus infections: lessons from animal models.the henipavirus genus contains two highly lethal viruses, the hendra and nipah viruses and one, recently discovered, apparently nonpathogenic member; cedar virus. these three, negative-sense single-stranded rna viruses, are hosted by fruit bats and use ephrinb2 receptors for entry into cells. the hendra and nipah viruses are zoonotic pathogens that emerged in the middle of 90s and have caused severe, and often fatal, neurologic and/or respiratory diseases in both humans and different animals; in ...201325437037
a key region of molecular specificity orchestrates unique ephrin-b1 utilization by cedar virus.the emergent zoonotic henipaviruses, hendra, and nipah are responsible for frequent and fatal disease outbreaks in domestic animals and humans. specificity of henipavirus attachment glycoproteins (g) for highly species-conserved ephrin ligands underpins their broad host range and is associated with systemic and neurological disease pathologies. here, we demonstrate that cedar virus (cedv)-a related henipavirus that is ostensibly nonpathogenic-possesses an idiosyncratic entry receptor repertoire ...202031862858
distinct cell transcriptomic landscapes upon henipavirus infections.hendra virus (hev) and cedar virus (cedv) are henipaviruses, which fall into the paramyxoviridae family of single-stranded, negative-sense rna viruses. hev is classified as a biosafety level-4 (bsl-4) agent, as it is highly pathogenic and is often fatal to humans. to date, no hev prevention or treatment methods for human are available. in contrast, previous experimental infection studies have suggested that cedv is non-pathogenic. flying foxes (pteropid bats) in australia are the natural reservo ...202032508793
hendra virus infection dynamics in the grey-headed flying fox (pteropus poliocephalus) at the southern-most extent of its range: further evidence this species does not readily transmit the virus to horses.hendra virus (hev) is an important emergent virus in australia known to infect horses and humans in certain regions of the east coast. whilst pteropid bats ("flying foxes") are considered the natural reservoir of hev, which of the four mainland species is the principal reservoir has been a source of ongoing debate, particularly as shared roosting is common. to help resolve this, we sampled a colony consisting of just one of these species, the grey-headed flying fox, (pteropus poliocephalus), at ...201627304985
nuclear localization and secretion competence is conserved amongst henipavirus matrix proteins.viruses of the genus henipavirus of the family paramyxoviridae are zoonotic pathogens, which have emerged in south east asia, australia and africa. nipah virus (niv) and hendra virus (hev) are highly virulent pathogens transmitted from bats to animals and humans, whilst the henipavirus cedar virus (cedv) seems to be non-pathogenic in infection studies. the full replication cycle of the paramyxoviridae occurs in the host cell's cytoplasm where viral assembly is orchestrated by the matrix (m) prot ...201728056216
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