| mucosal challenge ferret models of ebola virus disease. | recent studies have shown the domestic ferret (mustela putorius furo) to be a promising small animal model for the study of ebola virus (ebov) disease and medical countermeasure evaluation. to date, most studies have focused on traditional challenge routes, predominantly intramuscular and intranasal administration. here, we present results from a non-clinical pathogenicity study examining oronasal, oral, and ocular mucosal challenge routes in ferrets. animals were challenged with 1, 10, or 100 p ... | 2021 | 33806375 |
| the ferret as a model for filovirus pathogenesis and countermeasure evaluation. | the domestic ferret (mustela putorius furo) has long been a popular animal model for evaluating viral pathogenesis and transmission as well as the efficacy of candidate countermeasures. without question, the ferret has been most widely implemented for modeling respiratory viruses, particularly influenza viruses; however, in recent years, it has gained attention as a novel animal model for characterizing filovirus infections. although ferrets appear resistant to infection and disease caused by ma ... | 2021 | 33951727 |
| the domestic ferret (mustela putorius furo) as a lethal infection model for 3 species of ebolavirus. | small-animal models have been developed for several filoviridae species; however, serial adaptation was required to produce lethal infection. these adapted viruses have sequence changes in several genes, including those that modulate the host immune response. nonhuman primate models do not require adaptation of filoviruses. here, we describe lethal models of disease for bundibugyo, sudan, and zaire species of ebolavirus in the domestic ferret, using wild-type nonadapted viruses. pathologic featu ... | 2016 | 27354371 |