receptor usage of a novel bat lineage c betacoronavirus reveals evolution of mers-related coronavirus spike proteins for human dpp4 binding.although bats are known to harbor mers-cov-related viruses, the role of bats in the evolutionary origin and pathway remains obscure. we identified a novel mers-cov-related betacoronavirus, hp-batcov hku25, from chinese pipistrelle bats. while being closely related to mers-cov in most genome regions, its spike protein occupies a phylogenetic position between that of ty-batcov hku4 and pi-batcov hku5. since ty-batcov hku4 but not pi-batcov hku5 can utilize mers-cov receptor, hdpp4, for cell entry, ...201829346682
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