Publications

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genetic characterization of betacoronavirus lineage c viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus hku5 in japanese pipistrelle: implications for the origin of the novel middle east respiratory syndrome coronavirus.while the novel middle east respiratory syndrome coronavirus (mers-cov) is closely related to tylonycteris bat cov hku4 (ty-batcov hku4) and pipistrellus bat cov hku5 (pi-batcov hku5) in bats from hong kong, and other potential lineage c betacoronaviruses in bats from africa, europe, and america, its animal origin remains obscure. to better understand the role of bats in its origin, we examined the molecular epidemiology and evolution of lineage c betacoronaviruses among bats. ty-batcov hku4 and ...201323720729
discovery of novel bat coronaviruses in south china that use the same receptor as middle east respiratory syndrome coronavirus.middle east respiratory syndrome coronavirus (mers-cov) has represented a human health threat since 2012. although several mers-related covs that belong to the same species as mers-cov have been identified from bats, they do not use the mers-cov receptor, dipeptidyl peptidase 4 (dpp4). here, we screened 1,059 bat samples from at least 30 bat species collected in different regions in south china and identified 89 strains of lineage c betacoronaviruses, including tylonycteris pachypus coronavirus ...201829669833
replication of mers and sars coronaviruses in bat cells offers insights to their ancestral origins.previous findings of middle east respiratory syndrome coronavirus (mers-cov)-related viruses in bats, and the ability of tylonycteris-batcov hku4 spike protein to utilize mers-cov receptor, human dipeptidyl peptidase 4 hdpp4, suggest a bat ancestral origin of mers-cov. we developed 12 primary bat cell lines from seven bat species, including tylonycteris pachypus, pipistrellus abramus and rhinolophus sinicus (hosts of tylonycteris-batcov hku4, pipistrellus-batcov hku5, and sars-related-cov respec ...201830531999
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