Publications

TitleAbstractYear
Filter
PMID
Filter
tissue distribution of the mers-coronavirus receptor in bats.middle east respiratory syndrome coronavirus (mers-cov) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (dpp4) as its receptor. the distribution of dpp4 in the respiratory tract tissues of humans and camels reflects mers-cov tropism. apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for mers-like-covs. in order to gain insight on the tropism of these viruses in bats, we studied the dpp4 distribution in the respirator ...201728446791
species-specific colocalization of middle east respiratory syndrome coronavirus attachment and entry receptors.middle east respiratory syndrome coronavirus (mers-cov) uses the s1b domain of its spike protein to bind to dipeptidyl peptidase 4 (dpp4), its functional receptor, and its s1a domain to bind to sialic acids. the tissue localization of dpp4 in humans, bats, camelids, pigs, and rabbits generally correlates with mers-cov tropism, highlighting the role of dpp4 in virus pathogenesis and transmission. however, mers-cov s1a does not indiscriminately bind to all α2,3-sialic acids, and the species-specif ...201931167913
Displaying items 1 - 2 of 2