| tracing the sars-coronavirus. | four coronaviruses (hcov-229e, hcov-oc43, hcov-nl63, hcov-hku1) are endemic in humans and mainly associated with mild respiratory illnesses; whereas the other two coronaviruses [severe acute respiratory syndrome coronavirus (sars-cov) and middle east respiratory syndrome coronavirus (mers-cov)] present as emerging infections causing severe respiratory syndrome. coronaviruses evolve by accumulation of point mutations and recombination of genomes among different strains or species. mammalian coron ... | 2013 | 23977431 |
| abelson kinase inhibitors are potent inhibitors of severe acute respiratory syndrome coronavirus and middle east respiratory syndrome coronavirus fusion. | the highly pathogenic severe acute respiratory syndrome coronavirus (sars-cov) and middle east respiratory syndrome coronavirus (mers-cov) cause significant morbidity and morality. there is currently no approved therapeutic for highly pathogenic coronaviruses, even as mers-cov is spreading throughout the middle east. we previously screened a library of fda-approved drugs for inhibitors of coronavirus replication in which we identified abelson (abl) kinase inhibitors, including the anticancer dru ... | 2016 | 27466418 |