| a mouse model for mers coronavirus-induced acute respiratory distress syndrome. | middle east respiratory syndrome coronavirus (mers-cov) is a novel virus that emerged in 2012, causing acute respiratory distress syndrome (ards), severe pneumonia-like symptoms and multi-organ failure, with a case fatality rate of ∼36%. limited clinical studies indicate that humans infected with mers-cov exhibit pathology consistent with the late stages of ards, which is reminiscent of the disease observed in patients infected with severe acute respiratory syndrome coronavirus. models of mers-c ... | 2016 | 27892925 |
| permissivity of dpp4 orthologs to mers-coronavirus is governed by glycosylation and other complex determinants. | middle east respiratory syndrome coronavirus (mers-cov) utilizes dipeptidyl peptidase 4 (dpp4) as an entry receptor. while bat, camel, and human dpp4 support mers-cov infection, several dpp4 orthologs, including mouse, ferret, hamster, and guinea pig, do not. previous work revealed that glycosylation of mouse dpp4 plays a role in blocking mers-cov infection. here, we test whether glycosylation also acts as a determinant of permissivity for ferret, hamster, and guinea pig dpp4. we find that while ... | 2017 | 28747502 |