| engineering a stable cho cell line for the expression of a mers-coronavirus vaccine antigen. | middle east respiratory syndrome coronavirus (mers-cov) has infected at least 2040 patients and caused 712 deaths since its first appearance in 2012, yet neither pathogen-specific therapeutics nor approved vaccines are available. to address this need, we are developing a subunit recombinant protein vaccine comprising residues 377-588 of the mers-cov spike protein receptor-binding domain (rbd), which, when formulated with the addavax adjuvant, it induces a significant neutralizing antibody respon ... | 2018 | 29496347 |
| coronavirus interactions with the cellular autophagy machinery. | the covid-19 pandemic, caused by the sars-cov-2 virus, is the most recent example of an emergent coronavirus that poses a significant threat to human health. virus-host interactions play a major role in the viral life cycle and disease pathogenesis, and cellular pathways such as macroautophagy/autophagy prove to be either detrimental or beneficial to viral replication and maturation. here, we describe the literature over the past twenty years describing autophagy-coronavirus interactions. there ... | 2020 | 32964796 |