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adaptive evolution of mers-cov to species variation in dpp4.middle east respiratory syndrome coronavirus (mers-cov) likely originated in bats and passed to humans through dromedary camels; however, the genetic mechanisms underlying cross-species adaptation remain poorly understood. variation in the host receptor, dipeptidyl peptidase 4 (dpp4), can block the interaction with the mers-cov spike protein and form a species barrier to infection. to better understand the species adaptability of mers-cov, we identified a suboptimal species-derived variant of dp ...201830110630
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