| first detection of hepatitis e virus (orthohepevirus c) in wild brown rats (rattus norvegicus) from great britain. | in the united kingdom, there has been an increase in the number of hepatitis e virus (hev) infections in people annually since 2010. most of these are thought to be indigenously acquired orthohepevirus a genotype 3 (hev g3), which has been linked to pork production and consumption. however, the dominant subgroup circulating in british pigs differs from that which is found in people; therefore, an alternative, potentially zoonotic, source is suspected as a possible cause of these infections. rode ... | 2019 | 31033238 |
| hepatitis e virus in common voles (microtus arvalis) from an urban environment, hungary: discovery of a cricetidae-specific genotype of orthohepevirus c. | hepatitis e virus is a major causative agent of acute hepatitis worldwide. despite its zoonotic potential, there is limited information about the natural chain of hepevirus infection in wildlife, and the potential reservoir species. in this study, we performed a hev survey by heminested rt-pcr on rodent samples from an urban environment (in the city of pécs, hungary) and investigated the prevalence of the virus among these native rodent species (apodemus agrarius, apodemus flavicollis, apodemus ... | 2019 | 30499180 |
| spatial-temporal dynamics of hepatitis e virus infection in foxes (vulpes vulpes) in federal state of brandenburg, germany, 1993-2012. | hepatitis e virus (hev) is the main course for acute hepatitis in humans throughout the world. human associated genotypes 1 and 2 as well as zoonotic genotypes 3 and 4 are grouped in the species orthohepevirus a. in addition, a large variety of hev-related viruses has been found in vertebrates including carnivores, rats, bats, and chickens, which were classified in species orthohepevirus b-d. in 2015, partial genome sequences of a novel hepevirus were detected in feces of red foxes (vulpes vulpe ... | 2020 | 32082295 |
| characterization of a novel rat hepatitis e virus isolated from an asian musk shrew (suncus murinus). | the asian musk shrew (shrew) is a new reservoir of a rat hepatitis e virus (hev) that has been classified into genotype hev-c1 in the species orthohepevirus c. however, there is no information regarding classification of the new rat hev based on the entire genome sequences, and it remains unclear whether rat hev transmits from shrews to humans. we herein inoculated nude rats (long-evans rnu/rnu) with a serum sample from a shrew trapped in china, which was positive for rat hev rna, to isolate and ... | 2020 | 32630296 |
| genomic and spatial variability of a european common vole hepevirus. | rodents host different orthohepeviruses, namely orthohepevirus c genotype hev-c1 (rat hepatitis e virus, hev) and the additional putative genotypes hev-c3 and hev-c4. here, we screened 2,961 rodents from central europe by reverse transcription polymerase chain reaction (rt-pcr) and identified hev rna in 13 common voles (microtus arvalis) and one bank vole (myodes glareolus) with detection rates of 2% (95% confidence interval [ci]: 1-3.4) and 0.08% (95% ci: 0.002-0.46), respectively. sequencing o ... | 2019 | 31399875 |
| chevrier's field mouse (apodemus chevrieri) and père david's vole (eothenomys melanogaster) in china carry orthohepeviruses that form two putative novel genotypes within the species orthohepevirus c. | hepatitis e virus (hev) is the prototype of the family hepeviridae and the causative agent of common acute viral hepatitis. genetically diverse hev-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. in this study, we tested 278 specimens collected from seven wild small mammal species in yunnan province, china, for the presence and prevalence of orthohepevirus by broad-spectrum reverse transcription (rt)-pcr. hev-related sequences were detecte ... | 2018 | 29500690 |
| consensus proposals for classification of the family hepeviridae. | the family hepeviridae consists of positive-stranded rna viruses that infect a wide range of mammalian species, as well as chickens and trout. a subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. current published descriptions of the taxonomical divisions within the family hepeviridae are contradictory in relation to the assignment of species and genotypes. through analysis of existing sequence information ... | 2014 | 24989172 |
| identification of hepatitis e virus in the feces of red foxes (vulpes vulpes). | orthohepeviruses (hev) can infect a wide range of animals, showing a relatively strict host specificity; however, its zoonotic potential, natural transmission in the wildlife are less known. several new hev-like viruses have been identified in various animal species, including carnivores; however, the phylogenetic relationship among these viruses is poorly resolved, since some of them were known as rodent-related so far. the red fox, the most widespread carnivore worldwide, is a known reservoir ... | 2020 | 33050408 |
| detection of hepatitis e virus rna in rats caught in pig farms from northern italy. | hepatitis e virus (hev) strains belonging to the orthohepevirus genus are divided into four species (a-d). hev strains included in the orthohepevirus a species infect humans and several other mammals. among them, the hev-3 and hev-4 genotypes are zoonotic and infect both humans and animals, of which, pigs and wild boar are the main reservoirs. viruses belonging to the orthohepevirus c species (hev-c) have been considered to infect rats of different species and carnivores. recently, two studies r ... | 2020 | 31592576 |
| detection of rat hepatitis e virus, but not human pathogenic hepatitis e virus genotype 1-4 infections in wild rats from lithuania. | rat hepatitis e virus (hev) is an orthohepevirus which is related to other hev found in humans and other mammals. it was first identified in norway rats (rattus norvegicus) from germany in 2010, and later it has been detected in black rats (rattus rattus) and norway rats from usa, china, indonesia, vietnam and many european countries. in this study, we describe molecular and serological investigations of black and norway rats trapped in lithuania, eastern europe, for infections with rat hev and ... | 2018 | 29981698 |