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an evaluation of military sentry dogs as a sentinel system to everglades virus (venezuelan equine encephalitis fe3-7c strain). 1975812018
[the protective properties in mice of tonate virus and two strains of cabassou virus against neurovirulent everglades venezuelan encephalitis virus (author's transl)].venezuelan encephalitis virus is a constant menace to man and to animals, particularly horses. two as yet unreported strains have been isolated in french guyana: ca an 410d (tonate) and ca ar 508 (cabassou). they are not neurovirulent after peripheral inoculation into adult mice and guinea pigs. cabassou is not pathogenic for adult mice after intracerebral inoculation. a third strain, ca ar 19007, is antigenically identical by complement-fixation with cabassou, but appears to cross react with ot ...19761020877
[the protective properties in mice of tonate virus and two strains of cabassou virus against neurovirulent everglades venezuelan encephalitis virus (author's transl)].venezuelan encephalitis virus is a constant menace to man and to animals, particularly horses. two as yet unreported strains have been isolated in french guyana: ca an 410d (tonate) and ca ar 508 (cabassou). they are not neurovirulent after peripheral inoculation into adult mice and guinea pigs. cabassou is not pathogenic for adult mice after intracerebral inoculation. a third strain, ca ar 19007, is antigenically identical by complement-fixation with cabassou, but appears to cross react with ot ...19761020877
phylogenetic analysis of alphaviruses in the venezuelan equine encephalitis complex and identification of the source of epizootic viruses.we studied the evolution of alphaviruses in the venezuelan equine encephalitis (vee) complex using phylogenetic analysis of rna nucleotide sequences from limited portions of the nsp4, e1, and 3' untranslated genome regions of representative strains. the vee complex constituted a monophyletic group of viruses (descended from a common ancestor); some serologic vee varieties such as subtype iii formed monophyletic groups while subtype i did not. subtype ii everglades and variety id enzootic viruses ...19921413507
laboratory vector competence of culex (melanoconion) cedecei for sympatric and allopatric venezuelan equine encephalomyelitis viruses.laboratory vector competence of culex (melanoconion) cedecei was examined for venezuelan equine encephalomyelitis (vee) viruses. colonized adult female mosquitoes originating from a southern florida population were given bloodmeals from viremic hamsters circulating various titers of 3 hemagglutination inhibition (hi) subtypes of vee viruses. following extrinsic incubation of about 3 weeks, mosquitoes were allowed to refeed on uninfected hamsters for transmission trials. cx. cedecei was highly ef ...19863706626
everglades virus infection in man, 1975.within 72 hours of visiting the everglades national park in south florida, a 43-year-old man became ill with fever, malaise, myalgia, severe headache, pharyngitis, and enlarged, tender lymph nodes. everglades (venezuelan equine encephalomyelitis, subtype ii) virus was isolated from a blood sample drawn from the patient five days after onset of symptoms.19807444536
experimental everglades virus infection of cotton rats (sigmodon hispidus).everglades virus (evev), an alphavirus in the venezuelan equine encephalitis (vee) serocomplex, circulates among rodents and vector mosquitoes and infects humans, causing a febrile disease sometimes accompanied by neurologic manifestations. evev circulates near metropolitan miami, which indicates the potential for substantial human disease, should outbreaks arise. we characterized evev infection of cotton rats in south florida, usa, to validate their role in enzootic transmission. to evaluate wh ...200415663857
experimental everglades virus infection of cotton rats (sigmodon hispidus).everglades virus (evev), an alphavirus in the venezuelan equine encephalitis (vee) serocomplex, circulates among rodents and vector mosquitoes and infects humans, causing a febrile disease sometimes accompanied by neurologic manifestations. evev circulates near metropolitan miami, which indicates the potential for substantial human disease, should outbreaks arise. we characterized evev infection of cotton rats in south florida, usa, to validate their role in enzootic transmission. to evaluate wh ...200415663857
susceptibility of ochlerotatus taeniorhynchus and culex nigripalpus for eeverglades virus.everglades virus (evev), an alphavirus in the venezuelan equine encephalitis (vee) complex, is a mosquito-borne human pathogen endemic to south florida. field isolations of evev from culex (melanoconion) cedecei and laboratory susceptibility experiments established this species as its primary vector. however, isolates of evev from ochlerotatus taeniorhynchus and culex nigripalpus, more abundant and widespread species in south florida, suggested that they also transmit evev and could infect many ...200516014824
serologic evidence of widespread everglades virus activity in dogs, florida.everglades virus (evev), an alphavirus in the venezuelan equine encephalitis complex, circulates among rodents and vector mosquitoes in florida and occasionally infects humans. it causes febrile disease, sometimes accompanied by neurologic manifestations. although previous surveys showed high seroprevalence in humans, evev infections may be underdiagnosed because the disease is not severe enough to warrant a clinic visit or the undifferentiated presentations complicate diagnosis. documented evev ...200617326938
identification of culex (melanoconion) species of the united states using female cibarial armature (diptera: culicidae).species within the subgenus culex (melanoconion) theobald are the primary enzootic vectors of viruses in the venezuelan equine encephalitis complex including everglades virus, and probable enzootic vectors of eastern equine encephalitis and west nile viruses. adult females of this subgenus are often difficult or impossible to identify to species based on external morphological characters. the use of female cibarial armature allows for the identification of field-collected adult female specimens ...200919645276
culex (melanoconion) panocossa from peninsular florida, usa.culex (melanoconion) panocossa is a suspected vector of venezuelan equine encephalitis virus in central america. prior to this report, cx. panocossa was known from central america (belize, costa rica, el salvador, guatemala, southern mexico, panama), northern south america (colombia, venezuela) and the greater antilles (cuba and jamaica). larvae (n=5) and adults (n=4286) of cx. panocossa were collected at two locations near homestead, fl, which indicates substantial established populations of th ...201728012907
a humanised murine monoclonal antibody protects mice from venezuelan equine encephalitis virus, everglades virus and mucambo virus when administered up to 48 h after airborne challenge.currently there are no licensed antiviral treatments for the alphaviruses venezuelan equine encephalitis virus (veev), everglades virus and mucambo virus. we previously developed a humanised version of the mouse monoclonal antibody 1a3b-7 (hu1a3b-7) which exhibited a wide range of reactivity in vitro and was able to protect mice from infection with veev. continued work with the humanised antibody has now demonstrated that it has the potential to be a new human therapeutic. hu1a3b-7 successfully ...201222341308
mammal decline, linked to invasive burmese python, shifts host use of vector mosquito towards reservoir hosts of a zoonotic disease.invasive apex predators have profound impacts on natural communities, yet the consequences of these impacts on the transmission of zoonotic pathogens are unexplored. collapse of large- and medium-sized mammal populations in the florida everglades has been linked to the invasive burmese python, python bivittatus kuhl. we used historic and current data to investigate potential impacts of these community effects on contact between the reservoir hosts (certain rodents) and vectors of everglades viru ...201728978755
patterns of abundance, host use, and everglades virus infection in culex (melanoconion) cedecei mosquitoes, florida, usa.everglades virus (evev), subtype ii within the venezuelan equine encephalitis (vee) virus complex, is a mosquitoborne zoonotic pathogen endemic to south florida, usa. evev infection in humans is considered rare, probably because of the sylvatic nature of the vector, the culex (melanoconion) cedecei mosquito. the introduction of cx. panocossa, a tropical vector mosquito of vee virus subtypes that inhabits urban areas, may increase human evev exposure. field studies investigating spatial and tempo ...201931107225
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