complete nucleotide sequence of middelburg virus, isolated from the spleen of a horse with severe clinical disease in zimbabwe.the complete nucleotide sequence of middelburg virus (midv) was determined for strain midv-857 from zimbabwe. the isolation of this virus in 1993 from a horse that died showing severe clinical signs represents the first indication that midv can cause severe disease in equids. full-length cdna copies of the viral genome were successfully synthesized by an innovative rt-pcr amplification approach using an 'anchor primer' combined with the smart methodology described previously for the synthesis of ...200717947533
host and viral traits predict zoonotic spillover from mammals.the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...201728636590
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