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shifts in the antibiotic susceptibility, serogroups, and clonal complexes of neisseria meningitidis in shanghai, china: a time trend analysis of the pre-quinolone and quinolone eras.fluoroquinolones have been used broadly since the end of the 1980s and have been recommended for neisseria meningitidis prophylaxis since 2005 in china. the aim of this study was to determine whether and how n. meningitidis antimicrobial susceptibility, serogroup prevalence, and clonal complex (cc) prevalence shifted in association with the introduction and expanding use of quinolones in shanghai, a region with a traditionally high incidence of invasive disease due to n. meningitidis.201526057853
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