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prevalence of the prion protein gene e211k variant in u.s. cattle.in 2006, an atypical u.s. case of bovine spongiform encephalopathy (bse) was discovered in alabama and later reported to be polymorphic for glutamate (e) and lysine (k) codons at position 211 in the bovine prion protein gene (prnp) coding sequence. a bovine e211k mutation is important because it is analogous to the most common pathogenic mutation in humans (e200k) which causes hereditary creutzfeldt - jakob disease, an autosomal dominant form of prion disease. the present report describes a high ...200818625065
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