prevalence and molecular characterization of pertactin-deficient bordetella pertussis in the united states.pertussis has shown a striking resurgence in the united states, with a return to record numbers of reported cases as last observed in the 1950s. bordetella pertussis isolates lacking pertactin, a key antigen component of the acellular pertussis vaccine, have been observed, suggesting that b. pertussis is losing pertactin in response to vaccine immunity. screening of 1,300 isolates from outbreak and surveillance studies (historical isolates collected from 1935 up to 2009, isolates from the 2010 c ...201424256623
pertussis diagnoses among service members and other beneficiaries of the u.s. military health system, january 2005-june 2012.pertussis ("whooping cough") is a highly infectious respiratory disease caused by the bacterium bordetella pertussis. individuals at highest risk are infants and unvaccinated children; however, there have been recent increases in incidence among adolescent and young adult populations in the united states. during the surveillance period, there were 476 confirmed and 3,073 probable cases of pertussis among u.s. military members and other beneficiaries of the u.s. military health system. among serv ...201222963256
comparison of molecular detection methods for pertussis in children during a state-wide outbreak.a state-wide pertussis outbreak occurred in washington during the winter-spring months of 2012, concurrent with respiratory viral season. we compared performance characteristics of a laboratory-developed pertussis pcr (ld-pcr for bordetella pertussis, bordetella parapertussis, and bordetella holmesii) and rapid multiplex pcr (rm-pcr) for respiratory viruses (filmarray™, biofire, b. pertussis data unblinded following fda approval post outbreak). we analyzed three cohorts of patients using physici ...201627121506
infant pertussis epidemiology and implications for tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (tdap) vaccination: king county, washington, 2002 through describe the epidemiology of infant pertussis in king county, washington, and to better understand the implications for tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (tdap) vaccination among older children, adolescents, and adults.201121727277
antimicrobial susceptibility of bordetella pertussis isolates in the state of washington. 200717344029
molecular epidemiology of the pertussis epidemic in washington state in 2012.although pertussis disease is vaccine preventable, washington state experienced a substantial rise in pertussis incidence beginning in 2011. by june 2012, the reported cases reached 2,520 (37.5 cases per 100,000 residents), a 1,300% increase compared with the same period in 2011. we assessed the molecular epidemiology of this statewide epidemic using 240 isolates collected from case patients reported from 19 of 39 washington counties during 2012 to 2013. the typing methods included pulsed-field ...201425031439
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