| geographical distribution of cases of creutzfeldt-jakob disease in england and wales 1970-84. | two hundred and sixty seven patients with a definite or probable diagnosis of creutzfeldt-jakob disease (cjd) were identified in an attempt to ascertain all cases of the disease in england and wales in the period 1970-84. no evidence of space-time clustering of dates and places of onset was found for these cases. two age- and sex-matched controls were selected for 72 of the 122 cases diagnosed in the period 1980-84 and life histories of places of residence were obtained for these cases and the c ... | 1990 | 2199610 |
| increasing mortality from creutzfeldt-jakob disease in england and wales since 1979: ascertainment bias from increase in post-mortems? | creutzfeldt-jakob disease (cjd) is a rare and fatal dementing illness. a direct link has been proposed between cattle infected with bovine spongiform encephalopathy (bse) and a newly-identified variant of cjd. one possible explanation for the emergence of this new variant, together with a general increase in death due to classical cjd, would be ascertainment bias, due to an increase in the frequency of post-mortems in death attributed to dementia. this article uses national mortality records to ... | 1996 | 8895949 |
| epidemiological surveillance of creutzfeldt-jakob disease in the united kingdom. | systematic epidemiological surveillance of creutzfeldt-jakob disease was carried out in england and wales covering the years 1970-1984. the results of this work provide a basis from which to assess any change in the pattern of creutzfeldt-jakob disease following the occurrence of bovine spongiform encephalopathy. the methodology, early results and problems of the current systematic national survey of cjd, initiated in may 1990, are discussed. | 1991 | 1761103 |
| creutzfeldt-jakob disease in england and wales, 1980-1984: a case-control study of potential risk factors. | an attempt was made to ascertain all cases of creutzfeldt-jakob disease occurring in england and wales during the 5 year period 1980-1984. the mean annual mortality rate was 0.49/million; women were more frequently affected than men. the age-specific mortality rate reached a peak in the seventh decade. a case-control study involving 92 of the 122 definite and probable cases ascertained failed to confirm the reality of previously suspected aetiological agents in the environment. although there wa ... | 1988 | 3066847 |
| a retrospective study of creutzfeldt-jakob disease in england and wales 1970-1979. ii: epidemiology. | a comprehensive search yielded 121 confirmed cases of creutzfeldt-jakob disease who died in england and wales in the decade 1970-1979, 31 probable cases and 10 possible cases. descriptive epidemiological data are presented. the average annual incidence was 0.3 cases/million. an unexpected female excess was found. there was no evidence of space-time clustering of cases and no associations with occupation or past medical treatment were apparent. there was statistically significant variation in inc ... | 1986 | 3528394 |
| a retrospective study of creutzfeldt-jakob disease in england and wales 1970-79. i: clinical features. | a comprehensive search yielded 121 confirmed cases of creutzfeldt-jakob disease who died in england and wales in the decade 1970-79, and 31 probable cases. the clinical features and the results of investigation are described. three subgroups of patients were distinguished by clinical characteristics and contrasting course. | 1984 | 6368752 |
| epidemiology of creutzfeldt-jakob disease in england and wales. | some aspects of the epidemiology of creutzfeldt-jakob disease in england and wales in the decade 1964-73 were studied with the object of detecting evidence of natural transmission of this slow virus encephalopathy. some geographical clustering and possibility of contact between cases was found. | 1975 | 1097599 |