| demonstration of anti-disease immunity to plasmodium vivax malaria in sri lanka using a quantitative method to assess clinical disease. | clinical immunity to malaria was studied by quantifying the intensity of symptoms as well as by measurement of several hematologic indicators of pathology (the erythrocyte sedimentation rate [esr], serum bilirubin, reticulocyte count, plasma tumor necrosis factor-alpha [tnf-alpha], and blood glucose levels) in 39 plasmodium vivax malaria patients exposed to endemic malaria in southern sri lanka, and for comparison in 43 nonimmune patients who were residents of nonmalarious regions of the country ... | 1998 | 9502605 |
| characteristics of malaria transmission in kataragama, sri lanka: a focus for immuno-epidemiological studies. | parasitological and entomological parameters of malaria transmission were monitored for 17 months in 3,625 residents in a plasmodium vivax malaria endemic region in southern sri lanka; the study area consisted of 7 contiguous villages where routine national malaria control operations were being conducted. malaria was monitored in every resident; fever patients were screened and 4 periodical mass blood surveys were conducted. an annual malaria incidence rate of 23.1% was reported during the perio ... | 1990 | 2184688 |
| clustering of malaria infections within an endemic population: risk of malaria associated with the type of housing construction. | the occurrence of malaria infections due to plasmodium vivax and p. falciparum was monitored in a population of 3,023 people living in six contiguous villages in kataragama, an area of endemic malaria in southern sri lanka, over a period of 17 months. the annual incidence of malaria in this population during the study period was 25.8%. malaria attacks were clustered, occurring more frequently than expected in certain individuals and housing groups and less frequently than expected in others. in ... | 1991 | 1867350 |
| genetic complexity of plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite protein. | monoclonal antibodies against variant epitopes of a highly polymorphic protein (pv200) in schizonts of plasmodium vivax have been used to analyze the variety of genetically distinct populations of parasites present in the peripheral blood of individual p. vivax infections in sri lanka. in 9 out of 10 isolates of freshly drawn p. vivax infected blood from different individuals, parasites of only 1 pv200 serotype was found within each individual infection, even though parasites were serotypically ... | 1990 | 1690521 |
| transmission blocking immunity to human plasmodium vivax malaria in an endemic population in kataragama, sri lanka. | serum effects on gametocyte infectivity, that is, transmission blocking/enhancing immunity, were measured in the sera of 196 acute plasmodium vivax patients who were residents of a malaria region in kataragama, southern sri lanka. direct mosquito feedings were also performed on 170 of these patients. sera of about 48% of patients suppressed gametocyte infectivity significantly (by more than 75%) and of a smaller proportion (12%) had pronounced infectivity enhancing effects. transmission immunity ... | 1992 | 1437231 |
| genetic polymorphisms associated with anti-malarial antibody levels in a low and unstable malaria transmission area in southern sri lanka. | the incidence of malaria in sri lanka has significantly declined in recent years. similar trends were seen in kataragama, a known malaria endemic location within the southern province of the country, over the past five years. this is a descriptive study of anti-malarial antibody levels and selected host genetic mutations in residents of kataragama, under low malaria transmission conditions. | 2012 | 22905743 |