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ctx-m-5, a novel cefotaxime-hydrolyzing beta-lactamase from an outbreak of salmonella typhimurium in latvia.at a children's hospital in riga, latvia, isolates identified as salmonella typhimurium were found to be resistant to expanded-spectrum cephalosporins. two of the resistant strains were analyzed for the mechanism of cephalosporin resistance. isoelectric focusing revealed a common beta-lactamase with a pi of 8.8. in addition, one of the strains produced a pi 7.6 beta-lactamase. a transconjugant producing only the pi 7.6 enzyme was susceptible to expanded-spectrum cephalosporins; therefore, this e ...19989687393
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