| identification of a new mutagenic polychlorinated biphenyl derivative in the waka river, wakayama, japan, showing activation of an aryl hydrocarbon receptor-dependent transcription. | water samples from the waka river, which runs through an area housing many chemical industry facilities in wakayama, japan, have been found to show significant mutagenicity, especially without a mammalian metabolic activation system (s9 mix) in the salmonella typhimurium yg1024 strain. mutagens in the river water were adsorbed to 3 kg of blue cotton, extracted with methanol/ammonia, and separated by several low- and high-pressure liquid chromatography steps with reversed-phase columns. one mutag ... | 2002 | 11896690 |