| effect of okinawa propolis on pak1 activity, caenorhabditis elegans longevity, melanogenesis, and growth of cancer cells. | propolis from different areas has been reported to inhibit oncogenic/aging kinase pak1, which is responsible for a variety of conditions, including cancer, longevity, and melanogenesis. here, a crude extract of okinawa propolis (op) was tested against pak1 activity, caenorhabditis elegans (c. elegans) longevity, melanogenesis, and growth of cancer cells. we found that op blocks pak1 and exhibits anticancer activity in the a549 cell (human lung cancer cell) line with ic50 values of 6 μg/ml and 12 ... | 2016 | 27337169 |