| the prevalence of neutralizing antibodies against aav serotype 1 in healthy subjects in china: implications for gene therapy and vaccines using aav1 vector. | recombinant adeno-associated virus serotype 1 (aav1) has attracted tremendous interest as a promising vector for gene therapy and vaccine applications. however, the presence of aav1 neutralizing antibodies as a consequence of exposure to wild type aav1 can limit significantly effective gene transfer for biologics based aav1 vector. prior studies have reported that a prevalence of aav1 neutralizing antibodies ranged from 10% to 50% in different countries around the world, and up to 79% in dutch s ... | 2013 | 23852678 |