demonstration of a powerful mutagenic dinitropyrene in airborne particulate matter.of the many nitroarenes, dinitropyrenes (dnps) have the potential to revert salmonella typhimurium his- mutants. this study was conducted to investigate the potential mutagens present in airborne particulate matter collected in santiago, chile. 5 organic substances extracted with dichloromethane showed mutagenic rates of from 38.9 to 287 revertants per m3 of air for s. typhimurium his- strain ta98 without s9 mix. 4 of the samples had greatly reduced mutagenicity for strain ta98/1,8dnp6 but not f ...19836348530
mutagenicity of organic extracts from santiago (chile) airborne particulate matter.the ames test has been used to detect the mutagenic activity of organic extracts from santiago (chile) airborne particles collected in 1990 and 1991 in one of the monitoring net system stations (macam). the samples were assayed with the strains ta98, ta98-nr, and ta98/1,8-dnp6 of salmonella typhimurium, in the presence and in the absence of liver s9 fraction obtained from rats treated with aroclor 1254. with the strain ta98 all the samples showed a very high mutagenic response either in the pres ...19937688097
polycyclic aromatic hydrocarbon levels and mutagenicity of inhalable particulate matter in santiago, chile.the air in santiago, chile, is among the most highly polluted in the world. due to the high levels of pollutants and the high incidence of respiratory diseases, especially in the most susceptible groups, santiago has been declared a saturated zone for pm(10), o(3), and co. the aim of this work was to investigate polycyclic aromatic hydrocarbon levels and mutagenic activity of santiago s fine and coarse fractions of inhalable particles. the levels of 16 polycyclic aromatic hydrocarbons (pahs) wer ...200011114787
trends of polycyclic aromatic hydrocarbon levels and mutagenicity in santiago's inhalable airborne particles in the period 1992-1996.trends of polycyclic aromatic hydrocarbons (pahs) for 1992-1996 (cold season) and their mutagenic activity were investigated in organic extracts from the santiago, chile, inhalable particles (pm(10)). the highest pah concentrations were observed in 1992 and declined dramatically in the following years. during this period, total pahs decreased 85%, carcinogenic pahs 82%, and benzo[a]pyrene, the most potent carcinogen, 85%. in spite of this significant decrease, pah levels in respirable particles ...200011114788
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