| efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated plasmodium falciparum and plasmodium vivax in cambodia, 2008 to 2010. | we describe here the results of antimalarial therapeutic efficacy studies conducted in cambodia from 2008 to 2010. a total of 15 studies in four sentinel sites were conducted using dihydroartemisinin-piperaquine (dp) for the treatment of plasmodium falciparum infection and chloroquine (cq) and dp for the treatment of p. vivax infection. all studies were performed according to the standard world health organization protocol for the assessment of antimalarial treatment efficacy. among the studies ... | 2013 | 23208711 |
| ex vivo susceptibility of plasmodium falciparum to antimalarial drugs in western, northern, and eastern cambodia, 2011-2012: association with molecular markers. | in 2008, dihydroartemisinin (dha)-piperaquine (ppq) became the first-line treatment for uncomplicated plasmodium falciparum malaria in western cambodia. recent reports of increased treatment failure rates after dha-ppq therapy in this region suggest that parasite resistance to dha, ppq, or both is now adversely affecting treatment. while artemisinin (art) resistance is established in western cambodia, there is no evidence of ppq resistance. to monitor for resistance to ppq and other antimalarial ... | 2013 | 23939897 |
| assessing the asymptomatic reservoir and dihydroartemisinin-piperaquine effectiveness in a low transmission setting threatened by artemisinin resistant plasmodium falciparum. | in cambodia, elimination of artemisinin resistance through direct elimination of the plasmodium falciparum parasite may be the only strategy. prevalence and incidence at district and village levels were assessed in chey saen district, preah vihear province, north of cambodia. molecular and clinical indicators for artemisinin resistance were documented. | 2016 | 27585957 |
| plasmodium prevalence and artemisinin-resistant falciparum malaria in preah vihear province, cambodia: a cross-sectional population-based study. | intensified efforts are urgently needed to contain and eliminate artemisinin-resistant plasmodium falciparum in the greater mekong subregion. médecins sans frontières plans to support the ministry of health in eliminating p. falciparum in an area with artemisinin resistance in the north-east of cambodia. as a first step, the prevalence of plasmodium spp. and the presence of mutations associated with artemisinin resistance were evaluated in two districts of preah vihear province. | 2014 | 25288380 |