isolation and characterisation of p-eptx-ap1a and p-eptx-ar1a: pre-synaptic neurotoxins from the venom of the northern (acanthophis praelongus) and irian jayan (acanthophis rugosus) death adders. | the neurotoxicity observed following death adder envenoming has been thought to be solely due to the presence of potent post-synaptic neurotoxins. clinically, these effects are often poorly reversed by death adder antivenom or anticholinesterase, particularly when patients present with established paralysis. this suggests that either the post-synaptic neurotoxins are irreversible/'pseudo' irreversible, or the venom contains pre-synaptic neurotoxins that do not respond to antivenom. to support th ... | 2010 | 20488165 |
isolation and pharmacological characterization of a phospholipase a2 myotoxin from the venom of the irian jayan death adder (acanthophis rugosus). | 1. it has long been thought that death adder venoms are devoid of myotoxic activity based on studies done on acanthophis antarcticus (common death adder) venom. however, a recent clinical study reported rhabdomyolysis in patients following death adder envenomations, in papua new guinea, by a species thought to be different to a. antarcticus. consequently, the present study examined a. rugosus (irian jayan death adder) venom for myotoxicity, and isolated the first myotoxin (acanmyotoxin-1) from a ... | 2003 | 12540524 |