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pathobiological characterization of a novel reassortant highly pathogenic h5n1 virus isolated in british columbia, canada, 2015.in the current study, we describe the pathobiologic characteristics of a novel reassortant virus - a/chicken/bc/fav-002/2015 (h5n1) belonging to clade 2.3.4.4 that was isolated from backyard chickens in british columbia, canada. sequence analyses demonstrate pb1, pa, na and ns gene segments were of north american lineage while pb2, ha, np and m were derived from a eurasian lineage h5n8 virus. this novel virus had a 19 amino acid deletion in the neuraminidase stalk. we evaluated the pathogenic po ...201626988892
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