| isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from physalis angulata. | phytochemical investigation of physalis angulata was initiated following primary biological screening. fractionation of chcl3 and n-buoh solubles of the meoh extract from the whole plant was guided by in vitro cytotoxic activity assay using cultured hone-1 and nugc cells and led to the isolation of seven new withanolides, withangulatins b-h (1-7), and a new minor physalin, physalin w (8), along with 14 known compounds, including physaprun a, withaphysanolide, dihydrowithanolide e, physanolide a, ... | 2007 | 17580910 |