Publications

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resistance of cotton rats, sigmodon hispidus, to primary infection by nippostrongylus brasiliensis.the resistance of cotton rats, sigmodon hispidus to nippostrongylus brasiliensis infection was examined and compared the response to that of the susceptible indian soft-furred rat, millardia meltada. after a primary infection with infective third-stage n. brasiliensis larvae (l3), the number of eggs in feces and adult worm recovery rates from the small intestine of cotton rats were significantly lower than in the controls. to determine whether cotton rat resistance was observed during the migrat ...200212069075
the indian soft-furred rat, millardia meltada, a new host for nippostrongylus brasiliensis, showing androgen-dependent sex difference in intestinal mucosal defence.susceptibility of the indian soft-furred rat, millardia meltada, to infection with the intestinal helminth, nippostrongylus brasiliensis, was examined. after subcutaneous infection with 1500 infective larvae (l3), daily faecal egg output (epg) of both male and female animals reached a peak at 1 week post-infection (p.i.) with the same magnitude (about 20,000 epg faeces) and then rapidly decreased below detection level at around 2 weeks p.i. in male animals, however, after a transient cessation a ...19947883438
sensitive enzyme-linked immunosorbent assay (elisa) to measure parasite-specific antibodies of indian soft-furred rats, millardia meltada.immunoglobulin g (igg) of indian soft-furred rat, millardia meltada, was purified by an immunoaffinity chromatography and antibodies against it was raised in rabbit. using this rabbit anti-m. meltada igg antibody, sensitivity of enzyme-linked immunosorbent assay (elisa) to measure parasite-specific antibodies in the sera of m. meltada was markedly enhanced than the previous method using rabbit anti-mouse igg and rabbit anti-rat igg antibodies, which could cross-react to m. meltada igg. since m. ...19979234230
long-term survival of 'damaged' nippostrongylus brasiliensis adult worms in the testosterone-treated indian soft-furred rat, millardia meltada.when testosterone-treated female millardia meltada were infected with nippostrongylus brasiliensis, adult worms persisted for over seven weeks. the kinetics of faecal egg counts showed a biphasic pattern having a transient decline at around two weeks post infection (p.i.). thus the status of n. brasiliensis adult worms surviving in the small intestines of testosterone-treated m. meltada was examined. the fecundity and maturity of eggs in the uteri of female adult worms were examined at one, two, ...19979372513
effect of testosterone on the mucosal defence against intestinal helminths in indian soft-furred rats, millardia meltada with reference to goblet and mast cell responses.effects of testosterone on the mucosal defence mechanisms against intestinal helminths were examined in millardia meltada. when female m. meltada were treated with testosterone at the pharmacological dose, nippostrongylus brasiliensis infection persisted for over seven weeks with prominent biphasic pattern of faecal egg production, whereas almost complete expulsion was observed by two weeks in untreated controls. in spite of a biphasic pattern of faecal egg production, the worm burden of testost ...19958552417
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