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effect of ivermectin on two filaria-vector pairs. brugia malayi-aedes aegypti; litomosoides sigmodontis-bdellonyssus bacoti.the effect of ivermectin was studied on two filaria-vector pairs, brugia malayi-aedes aegypti and litomosoides sigmodontis-bdellonyssus bacoti. the rodent hosts, respectively mastomys coucha and meriones unguiculatus, were treated with ivermectin doses of 0.05 mg/kg, or 0.2 mg/kg or 2 mg/kg. batches of vectors were fed on rodents, infected or not, treated or not, from h7 to d43 post-ivermectin. vector survival was observed and dissections were performed to study the filarial development. it appe ...19938215116
immunomodulatory effects in litomosoides sigmodontis-infected mastomys coucha.the levels of parasite-specific igg1 and igg2 antibodies and mitogen-induced and parasite-specific proliferative t-cell responses were determined in litomosoides sigmodontis-infected mastomys coucha throughout an observation period of 400 days post infection (p.i.). these were compared with the respective reactions in animals that had been immunized with intrauterine stages/microfilariae of the parasite and in animals that had been challenged after immunization as determined at up to 60 days aft ...200010685840
filaricidal efficacy of anthelmintically active cyclodepsipeptides.pf 1022a, a novel anthelmintically active cyclodepsipeptide, and bay 44-4400, a semisynthetic derivative of pf 1022a were tested for filaricidal efficacy in mastomys coucha infected with litomosoides sigmodontis, acanthocheilonema viteae and brugia malayi. the parent compound pf 1022a showed limited anti-filarial efficacy in l. sigmodontis and b. malayi infected animals. oral doses of 5 x 100 mg/kg on consecutive days caused only a temporary decrease of microfilariaemia levels. by contrast, bay ...200111595239
effects of bay 44-4400, a new cyclodepsipeptide, on developing stages of filariae (acanthocheilonema viteae, brugia malayi, litomosoides sigmodontis) in the rodent mastomys coucha.bay 44-4400 was used as a spot on formulation and administered in single doses of 25 and 100 mg/kg to acanthocheilonema viteae, brugia malayi, and litomosoides sigmodontis infected mastomys coucha on various dates during prepatency, aiming to affect third stage larvae, fourth stage larvae or preadult worms. microfilaraemia levels were controlled in comparison to untreated controls until necropsies were performed 100 days p.i. (a. viteae, l. sigmodontis) and 150 days p.i. (b. malayi) to determine ...200111495640
juvenile female litomosoides sigmodontis produce an excretory/secretory antigen (juv-p120) highly modified with dimethylaminoethanol.a 120 kda antigen produced by juvenile female litomosoides sigmodontis (juv-p120) was isolated and purified. the amino acid composition of the molecule was determined. juv-p120 was shown to be highly modified with n,n-dimethyl-aminoethanol (28.4 mol%). treatment of juv-p120 with potassium hydroxide (beta-elimination) or with sodium m-periodate leads to the destruction of epitopes recognized by antibodies immune affinity-purified with isolated juv-p120. juvenile l. sigmodontis were shown to relea ...19989774792
antifilarial activity of caesalpinia bonducella against experimental filarial infections.lymphatic filariasis is a disabling disease that continues to cripple population in tropical countries. currently available antifilarial drugs are not able to control the disease. therefore, a better antifilarial is urgently required for proper management of the disease. we undertook this study to assess the antifilarial activity of caesalpinia bonducella-seed kernel against rodent filarial parasite in experimental model.200818820361
ultrasonography in filaria-infected rodents: detection of adult litomosoides sigmodontis and brugia malayi filariae.to evaluate the usefulness of ultrasonography (usg) in the detection of adult filariae in rodents. wuchereria bancrofti are frequently detected using usg in humans, whereas adult brugia malayi have not been so far.200616930260
the antifilarial activity of a marine red alga, botryocladia leptopoda, against experimental infections with animal and human filariae.the antifilarial activity of the marine red alga botryocladia leptopoda against rodent and human lymphatic filarial parasites is described. the animal filarial species included litomosoides sigmodontis and acanthocheilonema viteae maintained in cotton rats and mastomys coucha, respectively, while a subperiodic strain of the human lymphatic filarial parasite brugia malayi was maintained in m. coucha. the crude extract and its hexane fraction brought about a marked reduction in the peripheral micr ...200415243801
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