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a rhesus macaque model of pulmonary nontuberculous mycobacterial disease.in this study, we sought to develop a nonhuman primate model of pulmonary mycobacterium avium complex (mac) disease. blood and bronchoalveolar lavage fluid were collected from three female rhesus macaques infected intrabronchially with escalating doses of m. avium subsp. hominissuis. immunity was determined by measuring cytokine levels, lymphocyte proliferation, and antigen-specific responses. disease progression was monitored clinically and microbiologically with serial thoracic radiographs, co ...201626562499
quantitative image analysis of simian immunodeficiency virus replication in macrophages coinfected with mycobacterium avium complex.mycobacterium avium is the most frequent cause of disseminated bacterial infection in patients with human immunodeficiency virus type 1 infection and in rhesus macaques with simian immunodeficiency virus (siv) infection. this animal model of aids was used to test the hypothesis that this frequent association is the result of reciprocal enhancement of replication of both microorganisms. the replication of m. avium and siv was analyzed in lymphatic tissues obtained from rhesus macaques experimenta ...200010720506
antigenic stimulation in the simian model of hiv infection yields dilated cardiomyopathy through effects of tnfalpha.to investigate a role for endogenous myocardial cytokine production in the development of hiv-associated cardiomyopathy.200818316999
wasting syndrome and disruption of the somatotropic axis in simian immunodeficiency virus-infected macaques with mycobacterium avium complex infection.mycobacterium avium is a common opportunistic infection of patients with acquired immunodeficiency syndrome (aids). we used the simian immunodeficiency virus (siv)-infected rhesus macaque (macaca mulatta) model to examine whether disseminated m. avium is associated with disruption of the somatotropic axis in aids. macaques were followed prospectively, and body composition was determined by dual-energy x-ray absorption. serum levels of insulin-like growth factor (igf)-1, igf binding protein-3, gr ...200415551219
latent infection as a source of disseminated disease caused by organisms of the mycobacterium avium complex in simian immunodeficiency virus-infected rhesus macaques.whether infection with mycobacterium avium complex (mac) among patients with acquired immune deficiency syndrome results from recent exposure to virulent strains or reactivation of latent infection acquired years earlier is unknown. to address this question, tissue samples from 47 simian immunodeficiency virus (siv)-infected and 63 siv-uninfected rhesus macaques were cultured. mac was cultured from 14 siv-uninfected macaques (22.2%) and 32 siv-infected macaques (68.1%); median bacterial burdens ...200312751032
induction of disseminated mycobacterium avium in simian aids is dependent upon simian immunodeficiency virus strain and defective granuloma formation.mycobacterium avium complex (mac) is the most common disseminated bacterial disease in patients infected by the human immunodeficiency virus. although murine models of disseminated mac exist, they are primarily based on underlying genetic susceptibilities and cannot adequately address the complex interactions that occur between host, mycobacteria, and immunosuppressive lentivirus. to address this problem we have developed an experimental system to co-inoculate rhesus macaques with the simian imm ...200111485927
simian immunodeficiency virus-inoculated macaques acquire mycobacterium avium from potable water during aids.during the terminal stages of aids, mycobacterium avium complex (mac) infection is the most common disseminated bacterial infection in rhesus macaques (macaca mulatta) experimentally inoculated with the simian immunodeficiency virus (siv). the source of mycobacterial infection in 15 siv-inoculated rhesus macaques housed in a biolevel 3 containment facility was investigated using a sensitive polymerase chain reaction typing technique. six animal isolates had banding profiles identical to that of ...19978985217
unusual lesion morphology and skin test reaction for mycobacterium avium complex in macaques.three rhesus (macaca mulatta) and one cynomolgus (m. fascicularis) monkey were euthanized because of positive reactions to intradermal tests with mammalian old tuberculin (mot). all the animals had gross or microscopic lesions consisting of unitized macro- or microgranulomas with central necrosis, involving the lung or mesenteric lymph nodes. small numbers of acid fast organisms were demonstrated in the lesions. mycobacterium avium complex, serotype 2 was isolated from three of the cases. the ca ...19883367621
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