| effects of helicobacter pylori infection on gastric mucosal defense factors in japanese monkeys. | the pathogenic role played by helicobacter pylori in gastric mucosal defense was investigated in japanese monkeys infected with h. pylori. serum gastrin levels and ammonia concentrations in gastric juice were compared in h. pylori-infected (n = 6) and control (n = 7) groups. the gastritis score, the intracellular content of periodic acid-schiff (pas)-positive substance and hexosamine, and the bromodeoxyuridine (brdu) labeling index in the gastric mucosa were compared in the two groups in the ant ... | 1995 | 7550852 |
| establishment of an animal model for chronic gastritis with helicobacter pylori: potential model for long-term observations. | to assess the suitability of an established experimental model for chronic gastritis associated with helicobacter pylori for use in long-term observations. | 1994 | 7735940 |
| the novel anti-ulcer agent ecabet sodium (ta-2711) eradicates helicobacter pylori colonizing on the gastric mucosa of japanese monkeys. | | 1994 | 7871373 |
| [experimental study in japanese monkeys with helicobacter pylori infection]. | japanese monkeys were studied for one month from 6 months (short-term) after inoculation of helicobacter pylori, and two years (long-term). in the short-term study, macroscopic and histological gastritis were observed for 5 infected monkeys. the gastritis score, the ammonia concentration in the gastric secretion and the level of serum antibody (igg) were higher for the infected group than for the control. in the long term study, h. pylori was always recovered for 2 years in the infected group, a ... | 1993 | 8283620 |
| experimental gastritis induced by helicobacter pylori in japanese monkeys. | we used japanese monkeys (macaca fuscata) to establish an experimental model in order to clarify the pathogenicity of helicobacter pylori in gastric and duodenal disorders. a suspension (5 ml; 10(9) cfu/ml) of h. pylori cells isolated from humans was sprayed around the antrum of the stomach of each of 12 of 17 animals with an endoscope. the remaining five animals were not inoculated; they served as a control group. on days 7, 14, and 28 after inoculation, the gastric mucosa samples were examined ... | 1993 | 8432614 |
| ecabet sodium eradicates helicobacter pylori infection in gastric ulcer patients. | ecabet sodium (ecabet), a new agent that has protective effects on the gastric mucosa has anti-helicobacter pylori effects, binding with urease to inhibit h. pylori activity, and causing the bacterial to become non-viable. ecabet monotherapy eradicates h. pylori infection in japanese monkeys. we investigated a new regimen that included ecabet to eradicate h. pylori infection in gastric ulcer patients. fifty-five h. pylori-positive patients with gastric ulcer were randomly assigned to one of two ... | 1996 | 8959522 |
| helicobacter pylori infection delays the healing of acetic acid-induced gastric ulcer in japanese monkeys. | to clarify the relationship between helicobacter pylori and the healing of gastric ulcers, we investigated the healing of acetic acid-induced gastric ulcers in the antral mucosa of japanese monkeys (n = 5) infected with h. pylori and in control monkeys without h. pylori infection (n = 6). using h. pylori-infected japanese monkeys as an experimental model, gastric ulcers were induced endoscopically with acetic acid. healing of ulcers and factors that influenced healing were studied. continuous co ... | 1996 | 8985837 |
| long-term sequelae of experimental gastritis with helicobacter pylori: a 5-year follow-up study. | to investigate the long-term effects of helicobacter pylori gastritis on the gastric mucosa, 13 wild japanese monkeys (six h. pylori-infected and seven controls) were monitored for 5 years. colonization with h. pylori, the presence of macroscopic and histological gastritis, pyloric glandular height, and epithelial cell kinetics were investigated, using ki-67 immunostaining in the gastric mucosa. in the infected group, persistent colonization with h. pylori was demonstrated by culture and histopa ... | 1997 | 9479621 |
| [helicobacter pylori infection]. | since helicobacter pylori was first isolated by warren and marshall in 1983, many investigators have reported that it is closely associated with gastro-duodenal diseases. several diagnostic methods, c-urea breath tests, rapid urea test, histological exam and culture, are used for detecting h. pylori. japanese monkey and mongolian gerbils is the animal model that can sustain persistent colonization with h. pylori. japanese monkeys persistently infected with h. pylori can develop histological gast ... | 1998 | 9721527 |
| toxigenicity of helicobacter pylori isolates possessing caga gene and vacuolating cytotoxin. | inflammatory cells in the gastric epithelium and direct cell damage are important effects of h. pylori infection in causing gastroduodenal diseases. the aim of this study was to determine whether h. pylori possessing the caga gene and vacuolating cytotoxin activity (caga+/tox+) has these toxigenicities. the detection of caga was performed by the polymerase chain reaction method. culture supernatants of h. pylori were tested on rabbit gastric epithelial cell culture for intracellular vacuolation. ... | 1998 | 9840010 |
| helicobacter pylori infection affects gastric ulcer healing in japanese monkeys. | although peptic ulcer frequently recurs in the presence of helicobacter pylori infection, the effects of h. pylori on ulcer healing have yet to be studied in detail. using an animal model, we examined the effects of h. pylori infection on the healing of peptic ulcer in japanese macaques. forty-four japanese macaques, aged 5 years, were randomly divided into two groups, an h. pylori-infected group and a control group, with 22 animals in each. a total of 10(9) colony forming units per ml of an h. ... | 1998 | 9840013 |
| p53 expression in gastric mucosa with helicobacter pylori infection. | expression of p53 was examined immunohistochemically in the japanese monkey model with helicobacter pylori infection of the gastric mucosa to investigate the association between h. pylori infection and gastric carcinogenesis for a period of 4 years. in the course of these observations, from 3 years after h. pylori inoculation, nuclear staining for p53 was seen in the glandular cells of the mucosa infected with h. pylori, especially in the neck region of the glands. there was a gradual increase i ... | 1998 | 10221826 |
| [japanese monkey model of helicobacter pylori]. | | 2002 | 11979880 |
| long-term helicobacter pylori infection in japanese monkeys induces atrophic gastritis and accumulation of mutations in the p53 tumor suppressor gene. | helicobacter pylori is accepted as a definite human gastric carcinogen from an epidemiological point of view despite insufficient experimental data. although we previously showed that the number of p53 immunopositive cells in the atrophic gastric mucosa of h. pylori-infected japanese monkeys gradually increased over time, data on p53 gene mutations were not obtained in that study. to obtain direct evidence of carcinogenesis associated with h. pylori infection, we investigated whether p53 gene mu ... | 2002 | 12047319 |
| analysis of p53 mutations and helicobacter pylori infection in human and animal models. | p53 gene mutations are believed to play a critical role in the development of gastric carcinoma. we examined the relation between helicobacter pylori infection and p53 gene mutations of the gastric mucosa in human and animal models. | 2002 | 12109656 |
| helicobacter pylori and gastric carcinoma--from the view point of animal model. | many epidemiological studies have shown a strong association between chronic helicobacter pylori infection and subsequent development of gastric carcinoma in humans. to confirm this link more clearly, it is necessary to use this bacterium in experimental studies to develop gastric carcinoma in suitable experimental animals. persistent h. pylori infection has recently been achieved in the japanese monkeys and mongolian gerbil models, with results demonstrating that the sequential histopathologica ... | 2002 | 12528942 |
| animal models for the study of helicobacter-induced gastric carcinoma. | helicobacter pylori is considered to have a close association with gastric cancer. many epidemiological studies have shown a strong association between chronic h. pylori infection and subsequent development of gastric carcinoma in humans. to clarify this link more clearly, it is necessary to use this bacterium in experimental studies to develop gastric carcinoma in suitable experimental animals. persistent h. pylori infection was seen in the japanese monkey model, and has recently been achieved ... | 2004 | 15614454 |
| influence of antimicrobial treatment for helicobacter pylori infection on the intestinal microflora in japanese macaques. | eradication treatment for helicobacter pylori is known to cause mild but relatively frequent adverse effects. some adverse effects such as diarrhoea and soft stools are related to disruption of the composition of the intestinal microflora. this study investigated the microfloral changes resulting from administration of an eradication regimen using proton pump inhibitor (ppi), amoxycillin and clarithromycin. twenty-eight laboratory-bred japanese macaques either were administered eradication treat ... | 2005 | 15713617 |
| helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis. | although various animal models have been developed to clarify gastric carcinogenesis, apparent mechanism of gastric cancer was not clarified in recent years. since the recognition of the pathogenicity of helicobacter pylori (h pylori), several animal models with h pylori infection have been developed to confirm the association between h pylori and gastric cancer. nonhuman primate and rodent models were suitable for this study. japanese monkey model revealed atrophic gastritis and p53 mutation af ... | 2005 | 16437649 |